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PCB increases harmful effects of smoking

Date:
May 14, 2014
Source:
Uppsala University
Summary:
The harmful effect of smoking is aggravated if the person has high blood levels of PCB, research shows. This indicates that environmental contaminants interact with other risk factors for various diseases -- a field the researchers claim is under-researched. Also in former smokers the risk of dying was considerably higher among those who had high levels of PCB in their blood compared with those who had low levels (370 per cent greater risk, compared with 20 per cent). On the other hand, no elevated mortality was found among those who had never smoked.

It is well known that exposure to asbestos or radon drastically increases the injurious effects of smoking. In the present study, led by Uppsala University, the scientists have investigated whether high blood levels of the environmental contaminant PCB (polychlorinated biphenyls) reinforces the harmful effect of smoking.

The study was performed within the framework of the so-called PIVUS study, which comprehends some 1,000 70-year-old men and women in Uppsala. The results show that the risk of having died at the 8-year follow-up was 40 per cent higher for smokers with low levels of PCB in their blood compared with non-smokers. For smokers with high levels of PCB, the risk was fully 640 per cent higher.

Also in former smokers the risk of dying was considerably higher among those who had high levels of PCB in their blood compared with those who had low levels (370 per cent greater risk, compared with 20 per cent). On the other hand, no elevated mortality was found among those who had never smoked.

"These data show that exposure to PCB increases the risk dramatically in both smokers and former smokers. For non-smokers, no elevated risk was found, at any rate not after eight years. More studies are needed to clarify the risks for this group," says Lars Lind, professor of cardiovascular epidemiology at the Department of Medical Sciences, Uppsala University.

PCBs (Polychlorinated biphenyls) are a group of environmental contaminants that were banned nearly 20 years ago. But since they accumulate in the food chain and remain in the human body for a very long time, high levels can still be found in a majority of the population in Sweden and most other industrialised countries. High levels of PCBs have previously been shown to be linked to poor heart function, and for a number of risk factors for heart problems, such as obesity, diabetes and high blood pressure.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tahira Jamil, Carla Kruk, Cajo J. F. ter Braak. A Unimodal Species Response Model Relating Traits to Environment with Application to Phytoplankton Communities. PLoS ONE, 2014; 9 (5): e97583 DOI: 10.1371/journal.pone.0097583

Cite This Page:

Uppsala University. "PCB increases harmful effects of smoking." ScienceDaily. ScienceDaily, 14 May 2014. <www.sciencedaily.com/releases/2014/05/140514182719.htm>.
Uppsala University. (2014, May 14). PCB increases harmful effects of smoking. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2014/05/140514182719.htm
Uppsala University. "PCB increases harmful effects of smoking." ScienceDaily. www.sciencedaily.com/releases/2014/05/140514182719.htm (accessed August 20, 2014).

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