Featured Research

from universities, journals, and other organizations

Intensity modulated proton therapy shows benefit for head, neck cancer

Date:
May 27, 2014
Source:
University of Texas M. D. Anderson Cancer Center
Summary:
Ninety-three percent of head and neck cancer patients treated with multi-field optimization intensity modulated proton therapy (MFO-IMPT) were cancer-free 28 months after treatment, a small research study demonstrates. These preliminary results suggest that proton therapy may be an effective and less toxic treatment option for patients with head and neck cancer.

In a small study, researchers from The University of Texas MD Anderson Cancer Center found that 93 percent of head and neck cancer patients treated with multi-field optimization intensity modulated proton therapy (MFO-IMPT) were cancer-free 28 months after treatment. Side effects typical of standard radiation were also reduced in some cases. These preliminary results suggest that proton therapy may be an effective and less toxic treatment option for patients with head and neck cancer.

Related Articles


Published in the International Journal of Radiation, Oncology, Biology, Physics, the first of its kind study supports ongoing research by MD Anderson's Proton Therapy Center regarding the benefits of proton therapy and, most recently, MFO-IMPT, which is best used to deliver a precise dose of protons to the most complicated tumors -- ones that largely reside embedded in the nooks and crannies of the head and neck or at the base of the skull.

MFO-IMPT has the ability to spare surrounding healthy tissue from damage and help preserve quality of life measures such as neurocognitive function, vision, the ability to swallow, hearing, taste and speech. The current standard of treatment delivery for head and neck cancer, intensity modulated radiation therapy (IMRT), destroys both cancerous and healthy cells, impairing some of the functions listed above.

The prospective study followed 15 head and neck cancer patients: 10 squamous cell carcinoma (SCC) and five adenoid cystic carcinoma (ACC) cases treated with MFO-IMPT. Five of the SCC patients underwent induction chemotherapy before receiving proton therapy. All five ACC patients received chemotherapy concurrent with MFO-IMPT. At 28 months, all ten SCC patients and four of the ACC patients remained cancer-free. The results also showed a reduction in side effects:

•All patients completed treatment without any breaks, chemotherapy dose reductions or hospitalizations. •None of the patients who underwent MFO-IMPT with concurrent chemotherapy experienced nausea or vomiting. •Also, none of the patients experienced severe dermatitis (inflammation of the skin).

"Though early, this study provides the first evidence that proton therapy for head and neck cancers, which are becoming increasingly common, is safe and effective," said Steven J. Frank, M.D., Medical Director of the Proton Therapy Center, associate professor of Radiation Oncology at MD Anderson. "As incidence of HPV-related head and neck cancers rise, it's important to have treatment options that minimize long-term side effects. These patients are typically younger, are raising families and we hope have 30-40 years to look forward to as cancer survivors. The quality of those years is crucial."

According to Frank, also the study's lead author, ongoing research will determine if MFO-IMPT is able to reduce toxicity and improve survival.

MD Anderson treated its first MFO-IMPT patient in 2010; approximately 300 patients, many with complex head and neck cancers, have been treated with this form of proton therapy at the Proton Therapy Center to date.

Other MD Anderson researchers contributing to this study include James D. Cox, M.D., Michael Gillin, Ph.D., Radhe Mohan, Ph.D., Adam S. Garden, M.D., David I. Rosenthal, M.D., G. Brandon Gunn, M.D., Randal S. Weber, M.D., Merrill S. Kies, M.D., Jan S. Lewin, Ph.D., Mark F. Munsell, M.S., Matthew B. Palmer, B.S., Narayan Sahoo, Ph.D., Xiaodong Zhang, Ph.D., Wei Liu, Ph.D., and X. Ronald Zhu, Ph.D.


Story Source:

The above story is based on materials provided by University of Texas M. D. Anderson Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Steven J. Frank, James D. Cox, Michael Gillin, Radhe Mohan, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Randal S. Weber, Merrill S. Kies, Jan S. Lewin, Mark F. Munsell, Matthew B. Palmer, Narayan Sahoo, Xiaodong Zhang, Wei Liu, X. Ronald Zhu. Multifield Optimization Intensity Modulated Proton Therapy for Head and Neck Tumors: A Translation to Practice. International Journal of Radiation Oncology*Biology*Physics, 2014; DOI: 10.1016/j.ijrobp.2014.04.019

Cite This Page:

University of Texas M. D. Anderson Cancer Center. "Intensity modulated proton therapy shows benefit for head, neck cancer." ScienceDaily. ScienceDaily, 27 May 2014. <www.sciencedaily.com/releases/2014/05/140527154609.htm>.
University of Texas M. D. Anderson Cancer Center. (2014, May 27). Intensity modulated proton therapy shows benefit for head, neck cancer. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2014/05/140527154609.htm
University of Texas M. D. Anderson Cancer Center. "Intensity modulated proton therapy shows benefit for head, neck cancer." ScienceDaily. www.sciencedaily.com/releases/2014/05/140527154609.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins