Featured Research

from universities, journals, and other organizations

Sneaky bacteria change key protein's shape to escape detection

Date:
May 28, 2014
Source:
American Chemical Society
Summary:
Every once in a while in the US, bacterial meningitis seems to crop up out of nowhere, claiming a young life. Part of the disease's danger is the ability of the bacteria to evade the body's immune system, but scientists are now figuring out how the pathogen hides in plain sight.

Every once in a while in the U.S., bacterial meningitis seems to crop up out of nowhere, claiming a young life. Part of the disease's danger is the ability of the bacteria to evade the body's immune system, but scientists are now figuring out how the pathogen hides in plain sight. Their findings, which could help defeat these bacteria and others like it, appear in the Journal of the American Chemical Society.

Linda Columbus and colleagues explain that the bacteria Neisseria meningitidis, one cause of meningitis, and its cousin Neisseria gonorrhoeae, which is responsible for gonorrhea, have key-like proteins that allow them to enter human cells and do their damage. Gonorrhea can be cured, though one type of the responsible bacteria has reached "superbug" status, becoming resistant to known drugs. If meningitis is not treated immediately with antibiotics, it can cause severe disability and death. In a search for new ways to treat these diseases, scientists are looking more closely at how the bacteria sneak around in the body undetected. When someone gets an infection, specific proteins -- called antigens -- that stud the pathogen's outer layer usually raise an alarm, and the body's immune system goes on the attack. But these two kinds of Neisseria bacteria can elude the body's look-out cells, and Columbus' team wanted to know how.

They combined two approaches to figure out the architecture of one of the bacteria's outer proteins that help it gain entry into human cells. They found that the protein's outer loops that jostle against each other, causing their structure to constantly change. This shape-shifting makes for a kind of camouflage that hides them from the body's sentinels, at the same time preserving its ability to bind to and enter a person's cells. This deeper understanding could help lead to new treatments for bacterial diseases, the scientists state.

The authors acknowledge funding from the National Science Foundation, Cottrell Scholar Award, the University of Virginia nanoSTAR and the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel A. Fox, Per Larsson, Ryan H. Lo, Brett M. Kroncke, Peter M. Kasson, Linda Columbus. Structure of the Neisserial Outer Membrane Protein Opa60:Loop Flexibility Essential to Receptor Recognition and Bacterial Engulfment. Journal of the American Chemical Society, 2014; 140521092050002 DOI: 10.1021/ja503093y

Cite This Page:

American Chemical Society. "Sneaky bacteria change key protein's shape to escape detection." ScienceDaily. ScienceDaily, 28 May 2014. <www.sciencedaily.com/releases/2014/05/140528104949.htm>.
American Chemical Society. (2014, May 28). Sneaky bacteria change key protein's shape to escape detection. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/05/140528104949.htm
American Chemical Society. "Sneaky bacteria change key protein's shape to escape detection." ScienceDaily. www.sciencedaily.com/releases/2014/05/140528104949.htm (accessed July 23, 2014).

Share This




More Plants & Animals News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins