Featured Research

from universities, journals, and other organizations

Infant nutrition, development of type 1 diabetes: Is it possible to prevent the illness by splitting the proteins of cow's milk?

Date:
June 11, 2014
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
Splitting the cow’s milk proteins in a formula doesn’t prevent the start-up of the disease process of type 1 diabetes in predisposed children, shows a large international study. However, these results do not exclude the possibility that the early dietary modification may affect the latter phase in the disease process and so prevent the actual illness.

Splitting the cow's milk proteins in a formula doesn't prevent the start-up of the disease process of type 1 diabetes in predisposed children, shows a large international study. However, these results do not exclude the possibility that the early dietary modification may affect the latter phase in the disease process and so prevent the actual illness.

Previous studies have indicated that early exposure to complex foreign proteins, such as cow's milk proteins, increases the risk of type 1 diabetes in predisposed individuals. "Therefore, In 2002, we embarked on a large-scale study on more than 2100 infants with a family member affected by type 1 diabetes and with genetic disease susceptibility to find an answer to the question whether delaying the exposure to complex foreign proteins will decrease the risk of diabetes," tells Professor Mikael Knip from the University of Helsinki, the leader of the TRIGR Study.

After breastfeeding the babies were either weaned to a special formula, where the cow's milk proteins were split into small peptides, or to a conventional infant formula with the regular cow's milk proteins. The first study endpoint was positivity for at least two diabetes-associated autoantibodies by the age of six years.

The results show that there was no difference in the appearance of autoantibodies between the two study groups. However, the disease process resulting in clinical diabetes has clearly two phases, the first being the appearance of autoantibodies and the other the progression from autoantibody positivity to clinical disease.

"The current results do not exclude the possibility that the early dietary modification may affect the latter phase, and therefore it is extremely important to continue to follow the study participants into the final endpoint, which is the age of ten years. That endpoint will be reached in 2017," Professor Knip states.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. Mikael Knip, Hans K. Εkerblom, Dorothy Becker, Hans-Michael Dosch, John Dupre, William Fraser, Neville Howard, Jorma Ilonen, Jeffrey P. Krischer, Olga Kordonouri, Margaret L. Lawson, Jerry P. Palmer, Erkki Savilahti, Outi Vaarala, Suvi M. Virtanen. Hydrolyzed Infant Formula and Early β-Cell Autoimmunity. JAMA, 2014; 311 (22): 2279 DOI: 10.1001/jama.2014.5610

Cite This Page:

Helsingin yliopisto (University of Helsinki). "Infant nutrition, development of type 1 diabetes: Is it possible to prevent the illness by splitting the proteins of cow's milk?." ScienceDaily. ScienceDaily, 11 June 2014. <www.sciencedaily.com/releases/2014/06/140611093230.htm>.
Helsingin yliopisto (University of Helsinki). (2014, June 11). Infant nutrition, development of type 1 diabetes: Is it possible to prevent the illness by splitting the proteins of cow's milk?. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/06/140611093230.htm
Helsingin yliopisto (University of Helsinki). "Infant nutrition, development of type 1 diabetes: Is it possible to prevent the illness by splitting the proteins of cow's milk?." ScienceDaily. www.sciencedaily.com/releases/2014/06/140611093230.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) — Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) — A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) — A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins