Featured Research

from universities, journals, and other organizations

Vitamin D may play an important role in cancer prognosis

Date:
June 17, 2014
Source:
BMJ-British Medical Journal
Summary:
People with very low levels of vitamin D appear to be at higher risk of death from all causes (including cancer) and researchers say that vitamin D could play an important role in cancer prognosis. The main source of vitamin D is its production in skin thanks to the sun. Women are more prone to low vitamin D than men -- and due to differing weather conditions, concentrations vary in populations across the world.

The main source of vitamin D is its production in skin thanks to the sun. Women are more prone to low vitamin D than men -- and due to differing weather conditions, concentrations vary in populations across the world.

Vitamin D deficiency is especially common among the elderly who often have less sun exposure, but it is unclear what effect the production of vitamin D has on death.

So researchers investigated the association of vitamin D with deaths from all-causes, cardiovascular diseases and cancer. They paid particular attention to differences between countries, sexes and age groups.

Data were taken from seven population-based cohorts from the US and across Europe. All study participants were aged 50-79.

Results show that there was no clear trend of vitamin D by age, but average levels were consistently lower among women than men. Average levels increased with education, were lowest in obese individuals and higher among subjects who exercised.

During 16 years of follow-up, there were 6,695 deaths in 26,018 patients -- 2,624 from cardiovascular diseases and 2,227 from cancer.

An association was found between those with the lowest levels of vitamin D and death from cardiovascular disease -- in people with and without a history of the disease- and deaths from cancer in those with a history of the disease. No association was found between low vitamin D levels and deaths from cancer in those without a history of the disease.

The researchers say this shows an important role of vitamin D in the prognosis of cancer, although they add "we cannot exclude reverse causality, that is, that the cancer might have led to low vitamin D levels." There was also a dose-response relationship which was unchanged after excluding patients with a history of cardiovascular disease and cancer.

The researchers say that death from all causes as a result of low vitamin D has "high public health relevance" and should be given high priority. They also ask whether levels of vitamin D in specific countries, different sexes and seasons "should be considered for defining vitamin D deficiency" due to its varying levels.

They conclude that those with the lowest levels of vitamin D had an association "with increased all-cause mortality, cardiovascular mortality, and cancer mortality (in subjects with a history of cancer)." They say these effects were consistent across countries, sexes, age groups, and time of the year when blood tests were done and that "variation by geographic region, sex and season might need to be taken into account."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. Schottker, R. Jorde, A. Peasey, B. Thorand, E. H. J. M. Jansen, L. d. Groot, M. Streppel, J. Gardiner, J. M. Ordonez-Mena, L. Perna, T. Wilsgaard, W. Rathmann, E. Feskens, E. Kampman, G. Siganos, I. Njolstad, E. B. Mathiesen, R. Kubinova, A. Pajk, R. Topor-Madry, A. Tamosiunas, M. Hughes, F. Kee, M. Bobak, A. Trichopoulou, P. Boffetta, H. Brenner. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ, 2014; 348 (jun17 16): g3656 DOI: 10.1136/bmj.g3656

Cite This Page:

BMJ-British Medical Journal. "Vitamin D may play an important role in cancer prognosis." ScienceDaily. ScienceDaily, 17 June 2014. <www.sciencedaily.com/releases/2014/06/140617210845.htm>.
BMJ-British Medical Journal. (2014, June 17). Vitamin D may play an important role in cancer prognosis. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2014/06/140617210845.htm
BMJ-British Medical Journal. "Vitamin D may play an important role in cancer prognosis." ScienceDaily. www.sciencedaily.com/releases/2014/06/140617210845.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins