Featured Research

from universities, journals, and other organizations

Synaptic levels of clathrin protein are important for neuronal plasticity

Date:
June 19, 2014
Source:
IDIBELL-Bellvitge Biomedical Research Institute
Summary:
Asynaptic levels of the protein clathrin are a determinant factor for synaptic plasticity of neurons, researchers have shown. Neurons transmit information in a specialized contact points called synapses. These structures consist of two elements: the presynaptic one, information donor, and postsynaptic, which receives the information. New research is shedding light on the relationship between these.

Researchers of the group of cellular and molecular neurobiology of the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona, ​​led by researcher Artur Llobet, have shown that synaptic levels of the protein clathrin are a determinant factor for synaptic plasticity of neurons.

Chemical synapses and synaptic vesicular transmission cycle

Neurons transmit information in a specialized contact points called synapses. These structures consist of two elements: the presynaptic one, information donor, and postsynaptic, which receives the information. In the case of the presynaptic terminal, information is stored in vesicles containing neurotransmitters. When a stimulus arrives at the presynaptic terminal releases a vesicle by exocytosis. But to prevent the terminal to run out vesicles, immediately after exocytosis, occurs endocytosis. This coupling between exo and endocytosis defines what is known as vesicular synaptic vesicle cycle and is essential for neurons to release information correctly.

The vesicular cycle must adapt to constant changes in neuronal activity, and thus is a determinant of neuronal plasticity.

The dogma of the clathrin

Study investigators have sought to determine the role of clathrin in synaptic plasticity. "This protein is involved in all processes of endocytosis in all cells of the body and until now it was thought that it presents as abundant levels that it wouldn't pose a limiting factor" explained Artur Llobet.

"Our study," adds the researcher "questions this dogma because we found that in periods of intense neuronal stimulation, but within physiological levels, presynaptic levels of clathrin decrease reversibly. Ie levels clathrin are a dynamic property of the terminals."

"This is not surprising, what it is, is that a drop of only 20% are able to alter synaptic function. Specifically, this reduction reduces the number of vesicles that can be released, which has a direct action on exocytosis and therefore on the release of information. "

"In short," said Llobet "we showed that clathrin levels are a limiting factor for synaptic transmission, thus contributes to synaptic plasticity."


Story Source:

The above story is based on materials provided by IDIBELL-Bellvitge Biomedical Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francisco J. López-Murcia, Stephen J. Royle and Artur Llobet. Presynaptic Clathrin. Levels Are a Limiting Factor for Synaptic Transmission. The Journal of Neuroscience, June 2014 DOI: 10.1523/JNEUOSCI.5081-13.2014

Cite This Page:

IDIBELL-Bellvitge Biomedical Research Institute. "Synaptic levels of clathrin protein are important for neuronal plasticity." ScienceDaily. ScienceDaily, 19 June 2014. <www.sciencedaily.com/releases/2014/06/140619125319.htm>.
IDIBELL-Bellvitge Biomedical Research Institute. (2014, June 19). Synaptic levels of clathrin protein are important for neuronal plasticity. ScienceDaily. Retrieved August 31, 2014 from www.sciencedaily.com/releases/2014/06/140619125319.htm
IDIBELL-Bellvitge Biomedical Research Institute. "Synaptic levels of clathrin protein are important for neuronal plasticity." ScienceDaily. www.sciencedaily.com/releases/2014/06/140619125319.htm (accessed August 31, 2014).

Share This




More Mind & Brain News

Sunday, August 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) — Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) — A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com
Electrical Stimulation Boosts Brain Function, Study Says

Electrical Stimulation Boosts Brain Function, Study Says

Newsy (Aug. 29, 2014) — Researchers found an improvement in memory and learning function in subjects who received electric pulses to their brains. Video provided by Newsy
Powered by NewsLook.com
Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) — Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins