Featured Research

from universities, journals, and other organizations

Common BPA substitute, BPS, disrupts heart rhythms in females

Date:
June 23, 2014
Source:
Endocrine Society
Summary:
Bisphenol S (BPS), a common substitute for bisphenol A (BPA) in consumer products, may have similar toxic effects on the heart as previously reported for BPA, a new study finds.

Rat (stock image). Exposure to BPS rapidly increased the heart rate of female rats and under the stress condition led to arrhythmias -- heart rhythm abnormalities -- far greater than in the control rats that did not receive BPS.
Credit: artSILENSEcom / Fotolia

Bisphenol S (BPS), a common substitute for bisphenol A (BPA) in consumer products, may have similar toxic effects on the heart as previously reported for BPA, a new study finds. The results were presented Monday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

Related Articles


In the years since research evidence first showed many potentially damaging health effects of the industrial chemical BPA, some manufacturers have switched to its chemical cousin, BPS, to make hard plastics and other products that they call BPA free, said the study's lead investigator, Hong-Sheng Wang, PhD, from the University of Cincinnati.

Although some BPA-free products contain no bisphenols, Wang said, "BPS is one of the substitutes used in BPA-free products. There is implied safety in BPA-free products. The thing is, the BPA analogs -- and BPS is one of them -- have not been tested for safety in humans."

BPA is an endocrine (hormone) disrupter that can interfere with the actions of native estrogen and other hormones, but it is not clear whether BPS also is disrupts hormones.

In what Wang called "one of the first assessments of BPS' effect in mammalian primary cells or organs," he and his co-workers tested an environmentally relevant dose of BPS in the hearts of approximately 50 rats. The 1-nanomolar dose was in the range of BPS found in human urine samples in a study by other authors.

In the current study, the investigators perfused, or flowed, BPS through the arteries of each animal's pumping heart, after stimulating the heart with the hormone catecholamine to mimic stress. For a control group, 30 rat hearts received only catecholamine and no BPS.

Exposure to BPS rapidly increased the heart rate of female rats and under the stress condition led to arrhythmias -- heart rhythm abnormalities -- far greater than in the control rats that did not receive BPS, Wang reported. Electocardiograms demonstrated that BPS caused extra heartbeats and a racing heartbeat, also known as ventricular tachycardia. In male rats, BPS reportedly did not have this rapid impact on the heart.

To determine the cause of the cardiac effects in female rats, the researchers studied cardiac muscle cells from some of the rats. Using studies at the cellular and protein levels, they found that BPS caused abnormal calcium handling, or cycling, which is a key cause of arrhythmias, according to Wang. This action is very similar to the underlying mechanism of BPA's toxic effects on the heart, which Wang and his colleagues showed in a previous study.

The investigators were able to abolish the BPS-induced heart rhythm abnormalities by blocking a type of estrogen receptor (beta) in the female rats. This result shows that "the BPA analog BPS is not necessarily free of endocrine-disrupting activity," Wang said.

"Our findings call into question the safety of BPA-free products containing BPS," he said. "BPS and other BPA analogs need to be evaluated before further use by humans."

Grants from the National Institutes of Health and the University of Cincinnati Center for Environmental Genetics helped fund this work.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Common BPA substitute, BPS, disrupts heart rhythms in females." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623103935.htm>.
Endocrine Society. (2014, June 23). Common BPA substitute, BPS, disrupts heart rhythms in females. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2014/06/140623103935.htm
Endocrine Society. "Common BPA substitute, BPS, disrupts heart rhythms in females." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623103935.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins