Featured Research

from universities, journals, and other organizations

African American women more resistant to anti-inflammatory effect of aspirin than white women

Date:
June 23, 2014
Source:
Endocrine Society
Summary:
African American women respond differently to the anti-inflammatory effect of aspirin than do white American women, new research finds. Even though African American women have higher high-density lipoprotein (HDL, the "good" cholesterol) and lower triglyceride levels, they also have increased insulin resistance, oxidative stress burden, proinflammatory markers, HDL dysfunctionality -- and significantly higher mortality. Aspirin therapy has been recommended to reduce subclinical atherosclerosis and cardiovascular disease outcomes, including stroke.

African American women respond differently to the anti-inflammatory effect of aspirin than do white American women, new research finds. The results were presented at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.

"African American women appear to be more resistant than white American women to the anti-inflammatory benefits of aspirin in reducing cardiovascular disease and its risk factors," said lead study author Nora Alghothani, MD, MPH, endocrinology fellow in the Division of Endocrinology, Diabetes, & Metabolism at The Ohio State University in Columbus.

Even though African American women have higher high-density lipoprotein (HDL, the "good" cholesterol) and lower triglyceride levels, they also have increased insulin resistance, oxidative stress burden, proinflammatory markers, HDL dysfunctionality -- and significantly higher mortality. Aspirin therapy has been recommended to reduce subclinical atherosclerosis and cardiovascular disease outcomes, including stroke.

In their pilot study of 21 African American and 21 white American nondiabetic postmenopausal women with subclinical atherosclerosis, Dr. Alghothani and her colleagues randomly assigned half the women in each group to receive 325 mg of enteric-coated aspirin and half of them to receive an identical placebo, every day for 6 months.

The researchers looked at the subclinical pro-inflammatory markers hsCRP and IL-6 to compare the anti-inflammatory response to aspirin therapy between the AAW and WAW groups.

After 6 months, while hsCRP increased in both AAW and WAW placebo groups, and remained essentially unchanged in the aspirin-treated AAW group, it decreased by 25% in the aspirin-treated WAW group. While IL-6 increased in both placebo groups and in the aspirin-treated AAW group, it decreased by 48% in the aspirin-treated WAW group.

The African American women appeared to be more resistant to the anti-inflammatory properties of aspirin.

"Aspirin therapy has long been recommended to help reduce poor cardiovascular disease outcomes. Its benefits, however, may be different among African Americans compared with white Americans. This research shows an overall blunted response to the anti-inflammatory properties of aspirin among African Americans, and it suggests that a higher dose may be required in African Americans to achieve better cardiovascular disease prevention and lessen disparities among the different ethnic groups," Dr. Alghothani advised.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "African American women more resistant to anti-inflammatory effect of aspirin than white women." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623120053.htm>.
Endocrine Society. (2014, June 23). African American women more resistant to anti-inflammatory effect of aspirin than white women. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2014/06/140623120053.htm
Endocrine Society. "African American women more resistant to anti-inflammatory effect of aspirin than white women." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623120053.htm (accessed August 20, 2014).

Share This




More Mind & Brain News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Charter Schools Alter Post-Katrina Landscape

Charter Schools Alter Post-Katrina Landscape

AP (Aug. 20, 2014) Nine years after Hurricane Katrina, charter schools are the new reality of public education in New Orleans. The state of Louisiana took over most of the city's public schools after the killer storm in 2005. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Kids' Drawings At Age 4 Linked To Intelligence At Age 14

Newsy (Aug. 19, 2014) A study by King's College London says there's a link between how well kids draw at age 4 and how intelligent they are later in life. Video provided by Newsy
Powered by NewsLook.com
Mental, Neurological Disabilities Up 21% Among Kids

Mental, Neurological Disabilities Up 21% Among Kids

Newsy (Aug. 18, 2014) New numbers show a decade's worth of changes in the number of kids with disabilities. They suggest mental disabilities are up; physical ones are down. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins