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Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients

Date:
July 2, 2014
Source:
Henry Ford Health System
Summary:
An antibiotic therapy known to reduce catheter-related bloodstream infections in hemodialysis patients has been shown for the first time to reduce mortality, according to a study. Bloodstream infections are a leading cause of hospitalization and death in hemodialysis patients.

An antibiotic therapy known to reduce catheter-related bloodstream infections in hemodialysis patients has been shown for the first time to reduce mortality, according to a Henry Ford Health System study.

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Researchers found that a low-dose "lock" solution of gentamicin/citrate reduced mortality by 68 percent compared to a solution of heparin, a blood-clotting therapy long considered the standard of care. Additionally, the gentamicin/citrate solution was associated with a 73 percent reduction in bloodstream infections compared to the heparin treatment.

Bloodstream infections are a leading cause of hospitalization and death in hemodialysis patients.

The findings are published online in the Clinical Journal of the American Society of Nephrology, and will appear in the journal's July print edition. An editorial accompanies the study.

Jerry Yee, M.D., division head of Nephrology and Hypertension at Henry Ford and the study's senior author, says the findings suggest the antibiotic therapy is a potential game-changer for hemodialysis treatment.

"Advances in treatment have been elusive over the years. Perhaps our study can be a starting point to change the paradigm as a standard of care," Dr. Yee says. "The gentamicin/citrate solution was shown to be both safe and effective."

For their prospective, observational study involving 749 patients from September 2008 to June 2011, researchers compared the two therapeutic solutions. There were 427 patients in the heparin study arm and 322 in the gentamicin/citrate arm. The solutions were administered using an antibiotic locking-technique that prevents catheter clotting and reduces infection.


Story Source:

The above story is based on materials provided by Henry Ford Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. L. Moore, A. Besarab, M. Ajluni, V. Soi, E. L. Peterson, L. E. Johnson, M. J. Zervos, E. Adams, J. Yee. Comparative Effectiveness of Two Catheter Locking Solutions to Reduce Catheter-Related Bloodstream Infection in Hemodialysis Patients. Clinical Journal of the American Society of Nephrology, 2014; 9 (7): 1232 DOI: 10.2215/%u200BCJN.11291113

Cite This Page:

Henry Ford Health System. "Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients." ScienceDaily. ScienceDaily, 2 July 2014. <www.sciencedaily.com/releases/2014/07/140702122533.htm>.
Henry Ford Health System. (2014, July 2). Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2014/07/140702122533.htm
Henry Ford Health System. "Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients." ScienceDaily. www.sciencedaily.com/releases/2014/07/140702122533.htm (accessed November 23, 2014).

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