Featured Research

from universities, journals, and other organizations

How coffee protects against Parkinson's

Date:
July 10, 2014
Source:
Linköping Universitet
Summary:
A specific genetic variation discovered by researchers protects against Parkinson’s Disease – especially for those who drink a lot of coffee. Neurodegenerative diseases such as Parkinson's have a complicated background where both genetic factors and exposure to environmental factors are involved. In a study of a million genetic malformations, the research team identified a variant of the GRIN2A gene as a protective factor against Parkinson's. The corresponding protein is part of a complex that is thought to play a role in several neurodegenerative diseases.

A specific genetic variation discovered by researchers at Linköping University in Sweden protects against Parkinson's Disease -- especially for those who drink a lot of coffee.

The study is published in the scientific journal PLOS One.

Hereditary and environmental factors interact with one another in the emergence of diseases, and research is often focused on identifying genes and exposures that increase the risk for contracting diseases. But there are also genetic variations -- mutations -- and environmental factors that protect against the emergence of certain diseases.

Neurodegenerative diseases such as Parkinson's have a complicated background where both genetic factors and exposure to environmental factors are involved. In a study of a million genetic malformations, the research team identified a variant of the GRIN2A gene as a protective factor against Parkinson's. The corresponding protein is part of a complex that is thought to play a role in several neurodegenerative diseases.

An epidemiological study of Parkinson's patients from two counties in south east Sweden examined a combination of a previously known protective factor -- caffeine -- and the genetic variant in GRIN2A. The findings show that individuals with this combination run a significantly lower risk of developing the disease.

The study gives a molecular explanation to the protective effects that increased caffeine intake has on the development of Parkinson's. Caffeine integrates with a dopamine receptor that regulates the flow of calcium into the cell. As dopamine is part of the human reward system, and the interaction of caffeine with it, it has been speculated that individuals with certain genetic variations are not "rewarded" to the same extent by a cup of coffee, and therefore would not enjoy the same protective effect as others. The newly published study shows that GRIN2A can be a part of such a genetic predisposition.


Story Source:

The above story is based on materials provided by Linköping Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Naomi Yamada-Fowler, Mats Fredrikson, Peter Söderkvist. Caffeine Interaction with Glutamate Receptor Gene GRIN2A: Parkinson's Disease in Swedish Population. PLoS ONE, 2014; 9 (6): e99294 DOI: 10.1371/journal.pone.0099294

Cite This Page:

Linköping Universitet. "How coffee protects against Parkinson's." ScienceDaily. ScienceDaily, 10 July 2014. <www.sciencedaily.com/releases/2014/07/140710081304.htm>.
Linköping Universitet. (2014, July 10). How coffee protects against Parkinson's. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2014/07/140710081304.htm
Linköping Universitet. "How coffee protects against Parkinson's." ScienceDaily. www.sciencedaily.com/releases/2014/07/140710081304.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins