Featured Research

from universities, journals, and other organizations

PET/CT using leucocytes may detect infection in acute pancreatitis patients

Date:
August 5, 2014
Source:
Society of Nuclear Medicine
Summary:
A new study diagnosing infection in patients with pancreatic fluid collections may swiftly and accurately rule out active infection in the body, researchers report. This treatment may assist in bringing nuclear medicine to the forefront of clinical management.

A new study diagnosing infection in patients with pancreatic fluid collections may swiftly and accurately rule out active infection in the body. As reported in the August issue of The Journal of Nuclear Medicine, this treatment may assist in bringing nuclear medicine to the forefront of clinical management.

Acute pancreatitis (AP) is a sudden inflammation of the pancreas. It can have severe complications and high mortality despite treatment. While mildcases of AP are often successfully treated with conservative measures, such as nil per os (NPO) and aggressive intravenous fluid rehydration, severe cases may require admission to the intensive care unit or even surgery to deal with complications of the disease process. Early detection of infection in AP affects the choice of treatment and clinical outcome.

"Documenting infection of pancreatic necrosis/pancreatic or peripancreatic fluid collections is one of the key questions in managing such patients. So far only fine needle aspiration under radiological guidance could establish that with limitations of invasive procedure and at times insufficient amount of aspirate," said Anish Bhattacharya, MD, lead author of the study "PET/CT using 18F-fluorodeoxyglucose-labeled autologous leucocytes in the diagnosis of infected fluid collections in acute pancreatitis." He continued, "The present study, for the first time, gives evidence of a non-invasive investigation that can answer the question of infected pancreatic fluid collections. It even distinguishes two collections, one with and the other without infection. It could also be used to follow up with such patients after a radiological or endoscopic intervention."

In the study, researchers from the Postgraduate Institute of Medical Education and Research, Chandigarh, India, studied 41 patients, 28 male and 13 female, aged 21-69 with AP and radiological evidence of fluid collection in or around the pancreas. Leucocytes were separated from the patient's venous blood, labeled with 18F-fluorodeoxyglucose (FDG) and re-injected intravenously, followed by PET/CT imaging two hours later. A final diagnosis of infection was based on microbiological culture of fluid aspirated from the collection. Patients were managed with supportive care and antibiotics; percutaneous drainage/laparotomy were performed when indicated.

Blood glucose, total leucocyte count, neutrophil count and leucocyte labeling efficiency varied from 83 to 212 (11830) mg/100ml, 4600 to 24,200 (11648 5376)/mm3, 55% to 90% (73 10) and 31% to 97% (81 17) respectively. Increased tracer uptake was seen in the collection in 12 out of 41 patients; 10 had culture-proven infection and underwent percutaneous drainage, while aspiration was unsuccessful in two. The scan was negative for infection in 29 patients (25 out of 29 fluid cultures negative for infection and aspiration unsuccessful in four). Sensitivity, specificity and accuracy of the scan were 100% in 35 patients in whom fluid culture reports were available.

"This research uses a new technique to diagnose infection occurring in patients with pancreatic fluid collections. The patient is spared empirical antibiotic therapy or radiological intervention followed by time-consuming microbiological work-up," noted Bhattacharya.

The search for the ideal infection imaging radiopharmaceutical agent/technique has continued for several decades now, noted Bhattacharya. "This study suggests that PET-CT using FDG-labeled leucocytes may be useful in swiftly and accurately detecting or ruling out active infection in any part of the body, bringing nuclear medicine to the forefront of clinical management in these situations. This would encourage researchers to identify more such techniques in future," he said.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Bhattacharya, R. Kochhar, S. Sharma, P. Ray, N. Kalra, N. Khandelwal, B. R. Mittal. PET/CT with 18F-FDG-Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis. Journal of Nuclear Medicine, 2014; 55 (8): 1267 DOI: 10.2967/jnumed.114.137232

Cite This Page:

Society of Nuclear Medicine. "PET/CT using leucocytes may detect infection in acute pancreatitis patients." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805132003.htm>.
Society of Nuclear Medicine. (2014, August 5). PET/CT using leucocytes may detect infection in acute pancreatitis patients. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/08/140805132003.htm
Society of Nuclear Medicine. "PET/CT using leucocytes may detect infection in acute pancreatitis patients." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805132003.htm (accessed October 1, 2014).

Share This



More Matter & Energy News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Argentina's Tax Evaders Detected, Hunted Down by Drones

Argentina's Tax Evaders Detected, Hunted Down by Drones

AFP (Sep. 30, 2014) Argentina doesn't only have Lionel Messi the footballer, it has now also acquired "Mesi" the drone system which monitors undeclared mansions, swimming pools and soy fields to curb tax evasion in the country. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
CERN Celebrates 60 Years of Science

CERN Celebrates 60 Years of Science

Reuters - Business Video Online (Sep. 29, 2014) CERN, the European Organisation for Nuclear Research, celebrates 60 years of bringing nations together through science. As Joanna Partridge reports from inside the famous science centre it's also planning to turn the Large Hadron Collider particle accelerator back on after an upgrade. Video provided by Reuters
Powered by NewsLook.com
This 'Invisibility Cloak' Is Simpler Than Most

This 'Invisibility Cloak' Is Simpler Than Most

Newsy (Sep. 28, 2014) Researchers from the University of Rochester have created a type of invisibility cloak with simple focal lenses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins