Featured Research

from universities, journals, and other organizations

Heart failure is a substantial health burden in low- and middle-income countries

Date:
August 12, 2014
Source:
PLOS
Summary:
Heart failure is a major public health burden in many low- and middle-income countries, with substantial variation in the presentation, causes, management, and outcomes of heart failure across different LMICs, according to new research. The study also finds that a large proportion of patients are not receiving pharmacological treatments for heart failure.

Heart failure is a major public health burden in many low- and middle-income countries (LMICs), with substantial variation in the presentation, causes, management, and outcomes of heart failure across different LMICs, according to a study published in this week's PLOS Medicine. The study, led by Kazem Rahimi and colleagues from the George Institute for Global Health, also finds that a large proportion of patients are not receiving pharmacological treatments for heart failure.

Related Articles


The researchers conducted a systematic review and identified 49 published studies and 4 unpublished databases covering 31 countries and 237,908 hospitalizations for heart failure. By pooling the data from these studies, they found that the average age of patients admitted for acute heart failure was 63 years, which ranged from 42 years in Cameroon and Ghana to 75 years in Argentina, and correlated with the human development index (a measure of national well-being) of individual LMICs. The leading causes of heart failure differed across countries, with ischemic heart disease the most common cause in countries outside of Africa and the Americas, hypertension the most dominant cause in Africa (46%), and hypertension and ischemic heart disease similarly common in the Americas (31 and 33%, respectively). While 69% of heart failure patients in LMIC were prescribed diuretics, the three main treatments currently recommended in guidelines for managing heart failure -- angiotensin converting enzyme inhibitors, beta-blockers, and mineralocorticoid receptor agonists -- were prescribed at lower rates (57, 34, and 32%, respectively).

While the findings indicate that the burden of heart failure is substantial in LMICs, data from all LMICs were not available and the estimates are mostly derived from urban tertiary referral hospitals, therefore these findings may not reflect the broader picture of heart failure in the community in LMICs. The limited available data on and substantial impact of heart failure in LMIC emphasizes the need for more research attention in this area.

The authors stress the importance of this public health issue: "This review shows that heart failure places a considerable burden on health systems in LMICs, and affects a wide demographic profile of patients in these countries."

In a linked Perspective, Druin Burch examines how inconsistencies in diagnosis and selection of patients for clinical trials may contribute to treatment burden of heart failure in LMICs, saying: "The gap between suboptimal treatment of heart failure and what is achievable represents not just a failure to practice evidence-based medicine but a greater gap in knowledge and the research agenda."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas Callender, Mark Woodward, Gregory Roth, Farshad Farzadfar, Jean-Christophe Lemarie, Stéphanie Gicquel, John Atherton, Shadi Rahimzadeh, Mehdi Ghaziani, Maaz Shaikh, Derrick Bennett, Anushka Patel, Carolyn S. P. Lam, Karen Sliwa, Antonio Barretto, Bambang Budi Siswanto, Alejandro Diaz, Daniel Herpin, Henry Krum, Thomas Eliasz, Anna Forbes, Alastair Kiszely, Rajit Khosla, Tatjana Petrinic, Devarsetty Praveen, Roohi Shrivastava, Du Xin, Stephen MacMahon, John McMurray, Kazem Rahimi. Heart Failure Care in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. PLoS Medicine, 2014; 11 (8): e1001699 DOI: 10.1371/journal.pmed.1001699

Cite This Page:

PLOS. "Heart failure is a substantial health burden in low- and middle-income countries." ScienceDaily. ScienceDaily, 12 August 2014. <www.sciencedaily.com/releases/2014/08/140812163527.htm>.
PLOS. (2014, August 12). Heart failure is a substantial health burden in low- and middle-income countries. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/08/140812163527.htm
PLOS. "Heart failure is a substantial health burden in low- and middle-income countries." ScienceDaily. www.sciencedaily.com/releases/2014/08/140812163527.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins