Featured Research

from universities, journals, and other organizations

Antibiotics in early life may alter immunity long-term

Date:
August 18, 2014
Source:
University of British Columbia
Summary:
A new study aims to help scientists understand how different antibiotics affect bacteria that play a positive role in promoting a healthy immune system. “This is the first step to understanding which bacteria are absolutely necessary to develop a healthy immune system later in life,” says the lead researcher.

Most bacteria living in the gut play a positive role in promoting a healthy immune system, but antibiotic treatments often do not discriminate between good and bad bacteria. The study published today in Journal of Allergy and Clinical Immunology helps scientists understand how different antibiotics affect good bacteria.

between good and bad bacteria. The study published today in Journal of Allergy and Clinical Immunology helps scientists understand how different antibiotics affect good bacteria.

“This is the first step to understanding which bacteria are absolutely necessary to develop a healthy immune system later in life,” says Kelly McNagny, a professor in the Dept. of Medical Genetics who led the research along with UBC microbiologist Brett Finlay.

The researchers tested the impact of two antibiotics, vancomycin and streptomycin, on newborn mice. They found that streptomycin increased susceptibility to a disease known as hypersensitivity pneumonitis later in life, but vancomycin had no effect. The difference in each antibiotic’s long-term effects can be attributed to how they changed the bacterial ecosystem in the gut. Hypersensitivity pneumonitis is an allergic disease found in people with occupations such as farming, sausage-making, and cleaning hot tubs.

The researchers stress that infants should be treated with antibiotics when needed, but they hope these results will help pinpoint which bacteria make us less susceptible to disease. This could open up the possibility of boosting helpful bacteria through the use of probiotics.

“Probiotics could be the next big trend in parenting because once you know which bacteria prevent disease, you can make sure that children get inoculated with those bacteria,” says McNagny.


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shannon L. Russell, Matthew J. Gold, Lisa A. Reynolds, Benjamin P. Willing, Pedro Dimitriu, Lisa Thorson, Stephen A. Redpath, Georgia Perona-Wright, Marie-Renιe Blanchet, William W. Mohn, B. Brett Finlay, Kelly M. McNagny. Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. Journal of Allergy and Clinical Immunology, 2014; DOI: 10.1016/j.jaci.2014.06.027

Cite This Page:

University of British Columbia. "Antibiotics in early life may alter immunity long-term." ScienceDaily. ScienceDaily, 18 August 2014. <www.sciencedaily.com/releases/2014/08/140818095901.htm>.
University of British Columbia. (2014, August 18). Antibiotics in early life may alter immunity long-term. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/08/140818095901.htm
University of British Columbia. "Antibiotics in early life may alter immunity long-term." ScienceDaily. www.sciencedaily.com/releases/2014/08/140818095901.htm (accessed September 21, 2014).

Share This



More Plants & Animals News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) — The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) — Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins