Featured Research

from universities, journals, and other organizations

What Malignant Hyperthermia Association says about Ryanodex

Date:
September 2, 2014
Source:
Malignant Hyperthermia Association of the United States (MHAUS)
Summary:
The discovery and subsequent introduction of dantrolene in 1979 was a major breakthrough in the treatment of malignant hyperthermia (MH) that is responsible for saving hundreds, if not thousands, of lives. However, one of the major challenges in the successful treatment of MH is the need for rapid mixing, suspension, and administration of dantrolene during a crisis.

The discovery and subsequent introduction of dantrolene in 1979 was a major breakthrough in the treatment of malignant hyperthermia (MH) that is responsible for saving hundreds, if not thousands, of lives. However, one of the major challenges in the successful treatment of MH is the need for rapid mixing, suspension, and administration of dantrolene during a crisis.

Related Articles


Ryanodex® (Eagle Pharmaceuticals) is a new FDA approved preparation of dantrolene significantly speeds dantrolene preparation and administration. With Ryanodex, 250 mg of dantrolene can be suspended in 5 ml of sterile water for injection in less than 30 seconds and administered in less than one minute. Thus, an initial treatment dose of dantrolene of 2.5mg/kg for an 80 kg patient requires only 4 ml (200 mg) of Ryanodex.

Although efficacy of Ryanodex in treating MH in an established pig model has been demonstrated,1 the preparation has not yet been used to treat MH in humans. Now that FDA approval for the treatment of MH by Ryanodex has been granted, MHAUS recommends that The North American Malignant Hyperthermia Registry AMRA Report be utilized to report Ryanodex use. This will permit independent evaluation of its safety and efficacy in the treatment of human MH.


Story Source:

The above story is based on materials provided by Malignant Hyperthermia Association of the United States (MHAUS). Note: Materials may be edited for content and length.


Journal Reference:

  1. Jan K Schütte, Sandra Becker, Sascha Burmester, Alexander Starosse, Daniel Lenz, Lars Kröner, Frank Wappler, Mark U Gerbershagen. Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. European Journal of Anaesthesiology, 2011; 1 DOI: 10.1097/EJA.0b013e3283439545

Cite This Page:

Malignant Hyperthermia Association of the United States (MHAUS). "What Malignant Hyperthermia Association says about Ryanodex." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902114043.htm>.
Malignant Hyperthermia Association of the United States (MHAUS). (2014, September 2). What Malignant Hyperthermia Association says about Ryanodex. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2014/09/140902114043.htm
Malignant Hyperthermia Association of the United States (MHAUS). "What Malignant Hyperthermia Association says about Ryanodex." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902114043.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) — Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) — The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins