Reference Terms
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Antihistamine

An antihistamine is a drug which serves to reduce or eliminate effects mediated by histamine, an endogenous chemical mediator released during allergic reactions, through action at the histamine receptor.

Only agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines - other agents may have antihistaminergic action but are not true antihistamines.

Note:   The above text is excerpted from the Wikipedia article "Antihistamine", which has been released under the GNU Free Documentation License.
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September 1, 2015

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