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Pregnancy, Oral Contraceptives, Hormone Replacement Therapy As Risk Factors For Stroke

Date:
April 16, 1997
Source:
University of Maryland at Baltimore
Summary:
During the weeks immediately following delivery of a baby, new mothers are at increased risk of strokes, a University of Maryland School of Medicine neurology professor told the American Academy of Neurology meeting in Boston this week.
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During the weeks immediately following delivery of a baby, new mothersare at increased risk of strokes, a University of Maryland School ofMedicine neurology professor told the American Academy of Neurologymeeting in Boston this week.

Speaking on stroke prevention in the `90s, Dr. Steven Kittner,associate professor of neurology at the medical school in Baltimore,presented data from observational studies indicating a 28-foldincreased risk of intracerebral hemorrhage and a nine-fold increase inrisk of cerebral infarction in women during the six weeks afterdelivery.

Pregnancy itself is associated with no increased risk of cerebralinfarction and only a modestly increased risk of intracerebralhemorrhage, Kittner said.

Oral contraceptives seem to cause a dose-associated increased risk ofstroke, said Kittner. "Current research supports the accepted practiceof restricting the use of oral contraceptives in women who smokecigarettes, have a history of hypertension or other risk factors forvascular disease," he said.

The relationship between postmenopausal estrogen replacement therapyand stroke remains less clear, the neurologist said. One large studyshowed a significantly increased risk of stroke both among womentaking estrogen alone and those taking combination hormone replacementtherapy of estrogen and progestin. But another study showed asignificantly reduced risk of stroke in women taking combinationhormone replacement therapy.

Several large clinical trials now under way should provide moredefinitive data, but for now, "there still are only two wellestablished indications for hormone replacement therapy, relief ofmenopausal symptoms and prevention of osteoporosis," Kittner said. "Many uncertainties persist regarding the risk of combinedestrogen-progestin therapy, and the risks/benefits need to be weighedin each individual case.


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The above post is reprinted from materials provided by University of Maryland at Baltimore. Note: Materials may be edited for content and length.


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University of Maryland at Baltimore. "Pregnancy, Oral Contraceptives, Hormone Replacement Therapy As Risk Factors For Stroke." ScienceDaily. ScienceDaily, 16 April 1997. <www.sciencedaily.com/releases/1997/04/970416205544.htm>.
University of Maryland at Baltimore. (1997, April 16). Pregnancy, Oral Contraceptives, Hormone Replacement Therapy As Risk Factors For Stroke. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/1997/04/970416205544.htm
University of Maryland at Baltimore. "Pregnancy, Oral Contraceptives, Hormone Replacement Therapy As Risk Factors For Stroke." ScienceDaily. www.sciencedaily.com/releases/1997/04/970416205544.htm (accessed September 1, 2015).

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