Featured Research

from universities, journals, and other organizations

Jackson Lab Scientists Report Advance In Study Of Neuronal Migration In Brain Development

Date:
April 24, 1997
Source:
The Jackson Laboratory
Summary:
Genetic research conducted at The Jackson Laboratory has identified a protein in mice that may play a fundamental role in the critical process of "wiring" the central nervous system during vertebrate embryonic development.





FOR IMMEDIATE RELEASE
APRIL 24, 1997



BAR HARBOR -- Genetic research conducted at The Jackson Laboratory has identified a protein in mice that may play a fundamental role in the critical process of "wiring" the central nervous system during vertebrate embryonic development.


The abnormalities observed in mouse models bred at the Laboratory with mutations in the rcm (rostral cerebellar malformation) gene involve significant disruption of neuronal migration during development of the brain. Such genetic mutations in human brain development are known to result in disorders including epilepsy and severe mental retardation.


The study -- led by Susan L. Ackerman, Research Scientist at The Jackson Laboratory -- is reported in the April 24 issue of the journal Nature under the title, "The Mouse Rostral Cerebellar Malformation Gene Encodes an UNC-5 like Protein." Co-authors are Leslie P. Kozak, Stefan A. Przyborski, and Barbara B. Knowles, all of The Jackson Laboratory; and Laurie A. Rund, University of Illinois, Urbana, and Bert B. Boyer, University of Alaska, Fairbanks, both formerly of the Laboratory.


"This will have an impact on our understanding of how the human brain develops," says Dr. Ackerman. "This mouse mutant is unique in that it has cerebellar neurons in a completely different region of the brain. Our results support a fundamental role for the rcm protein in critical migratory events during cerebellar development."


Research in mice and other animals has shed light on the complex process of central nervous system development. Billions of neurons from "nurseries" deep within the brain are born and differentiated at specific times and migrate to precise locations in the central nervous system, where they are wired into the intricate circuit that assures the proper functioning of the brain.


But sometimes the migratory process goes astray, with neurons failing to reach the proper destinations and instead forming jumbled-up concentrations in other regions of the brain. In humans, this can result in conditions such as lissencephaly, or "smooth brain," in which the cerebral cortex lacks the normal surface texture. Lissencephalic children seldom survive, suffering severe mental retardation and seizures from birth.


The scientists report in Nature that the rcm mouse exhibits a dramatic reduction in cerebellar size and in cerebellar folding; that ectopic cerebellar cells are present in midbrain regions by three days after birth; and that postnatal cerebellar neuronal migration abnormalities are present. The mouse is also ataxic, or stumbling, in its gait.


The rcm gene is a member of a newly described family of vertebrate homologues of unc-5 (uncoordinated), a protein that has been found to be essential for normal cell migration during the development of the worm, C. elegans, which suggests an evolutionary conservation of gene function between invertebrates and mammals.


Story Source:

The above story is based on materials provided by The Jackson Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

The Jackson Laboratory. "Jackson Lab Scientists Report Advance In Study Of Neuronal Migration In Brain Development." ScienceDaily. ScienceDaily, 24 April 1997. <www.sciencedaily.com/releases/1997/04/970424081557.htm>.
The Jackson Laboratory. (1997, April 24). Jackson Lab Scientists Report Advance In Study Of Neuronal Migration In Brain Development. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/1997/04/970424081557.htm
The Jackson Laboratory. "Jackson Lab Scientists Report Advance In Study Of Neuronal Migration In Brain Development." ScienceDaily. www.sciencedaily.com/releases/1997/04/970424081557.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins