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Blood-Thinning Drug May Improve Clot-Busting Treatment, Save Lives

Date:
October 6, 1997
Source:
American Heart Association
Summary:
For treating heart attacks, the blood thinner hirulog is better than heparin when added to a "clot-buster" to dissolve blood clots and reopen clogged arteries, according to a report in today's American Heart Association journal Circulation.

DALLAS, Oct. 7 -- For treating heart attacks, the blood thinner hirulogis better than heparin when added to a "clot-buster" to dissolve blood clots andreopen clogged arteries, according to a report in today's American HeartAssociation journal Circulation.

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New Zealand researchers found that individuals given hirulog were morelikely to have their arteries "open up" following the clot-busting orthrombolytic treatment. Streptokinase was the thrombolytic used in this study.

"At 48 hours, the artery has opened up in 35 percent of heparin and 48percent of high-dose hirulog patients," reports Harvey White, M.D., of thecardiology department at Green Lane Hospital. The study included 412 patients:140 were given heparin, 136 were given low-dose hirulog and 136 were givenhigh-dose hirulog.

Researchers point out that within the first 24 hours after clot-busingtreatment, about 5-15 percent of individuals may have new clots forming, aproblem that, in some cases, causes death.

White says a large clinical trial will be conducted in 17,000 patientsto find out if hirulog given before streptokinase will improve survival. Earlysuccessful reperfusion or reopening is normally associated with survival.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Blood-Thinning Drug May Improve Clot-Busting Treatment, Save Lives." ScienceDaily. ScienceDaily, 6 October 1997. <www.sciencedaily.com/releases/1997/10/971006205252.htm>.
American Heart Association. (1997, October 6). Blood-Thinning Drug May Improve Clot-Busting Treatment, Save Lives. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/1997/10/971006205252.htm
American Heart Association. "Blood-Thinning Drug May Improve Clot-Busting Treatment, Save Lives." ScienceDaily. www.sciencedaily.com/releases/1997/10/971006205252.htm (accessed March 28, 2015).

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