Featured Research

from universities, journals, and other organizations

Search And Destroy -- Molecular Cancer Drug Delivery System Shown To Reduce Toxicity

Date:
November 5, 1997
Source:
University Of Maryland
Summary:
Researchers at the University of Maryland School of Pharmacy are developing a new drug delivery system that greatly reduces toxicity of chemotherapy drugs.

Chemotherapy works because it kills cancer cells. Unfortunately, thedrugs can also kill healthy cells as they pass through the body on theirway to the cancerous target. Many are so toxic they never make it tomarket.

But researchers at the University of Maryland School ofPharmacy are developing a new drug delivery system that greatly reducestoxicity.

Parshant Chikhale, Ph.D., assistant professor, and colleagues reportthat their system delivers anti-cancer drugs directly to tumor sites,controls the delivery speed, and will not harm brain tissue.

The researchers are reporting on three studies that indicate the noveldelivery system will release the drugs only in the presence of a tumor.Drug release can be controlled with this system because the bond betweena novel carrier molecule and the drug can only be broken in theenvironment found in the presence of cancerous tissue.

By modifying thestructure of the molecule, the researchers also were able to decreaseand increase the speed of the chemical reaction releasing the drug.Chikhale also reports that binding amino acid-based anti-cancer agentsto their molecule rendered the drugs unable to permeate the blood-brainbarrier, avoiding toxicity to the brain.

Chikhale will present the findings at Annual Meeting of the American Association ofPharmaceutical Scientists this week in Boston.


Story Source:

The above story is based on materials provided by University Of Maryland. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland. "Search And Destroy -- Molecular Cancer Drug Delivery System Shown To Reduce Toxicity." ScienceDaily. ScienceDaily, 5 November 1997. <www.sciencedaily.com/releases/1997/11/971105064731.htm>.
University Of Maryland. (1997, November 5). Search And Destroy -- Molecular Cancer Drug Delivery System Shown To Reduce Toxicity. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/1997/11/971105064731.htm
University Of Maryland. "Search And Destroy -- Molecular Cancer Drug Delivery System Shown To Reduce Toxicity." ScienceDaily. www.sciencedaily.com/releases/1997/11/971105064731.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins