Featured Research

from universities, journals, and other organizations

UNM Health Sciences Center Researchers Develop Method To Stimulate Immune System Response Against Cancer And Infectious Diseases

Date:
March 13, 1998
Source:
University Of New Mexico
Summary:
Researchers at the University of New Mexico Health Sciences Center have developed a one-step method to create patient-specific vaccines against cancers and infectious diseases. These "customized" vaccines are made by combining heat shock proteins with tumor antigen proteins obtained from tumor masses removed from the body.

Researchers at the University of New Mexico Health Sciences Center have developed a one-step method to create patient-specific vaccines against cancers and infectious diseases. These "customized" vaccines are made by combining heat shock proteins with tumor antigen proteins obtained from tumor masses removed from the body.

Heat shock proteins, also known as HSPs, are found in every cell of every living organism, from bacteria to plants to man. Researchers don't totally understand the role of HSPs within the human body. What is known is that HSPs act as chaperons, helping to move other proteins from one part of the cell to another.

Recent research suggests that HSPs might also serve as a danger signal, activating the body's immune system response to fight the cancer. However, HSPs alone can not trigger the immune system. Instead, HSPs serve as carriers of specific tumor antigens. The HSPs must be attached to protein antigens from the specific tumor and transport those proteins to the body's immune cells.

"Our research team believes that the cancer itself is not the key problem. All of us may have hundreds of cancers in our lifetime, but our immune system recognizes these abnormalities and removes them before they can develop into disease. The problem is when our immune system is unable to recognize the cancer cells and is therefore unable to combat the tumor. When heat shock proteins are combined with protein antigens from a specific tumor, this enables the body*s immune system to recognize the type of cancer cells and elicit an appropriate immune response,* said Pope Moseley, M.D., chief of the UNM School of Medicine*s Pulmonary, Allergy and Critical Care Division, within the Department of Internal Medicine. UNM researchers devised a simple, one-step method to purify the HSP-tumor antigen protein complex. The tumor-specific vaccine is synthesized by purifying the HSP-containing fraction of tumor cells which are limited to the tumor antigens. The protein complex that is produced, then has the ability to trigger the desired tumor immune response. UNM is currently seeking to license this technology.

"There has been a phenomenal explosion in heat shock protein research. Cancer immunotherapy is one of the exciting new areas in cancer research.This technology is suitable for kit applications, making it possible for any hospital or other setting to conveniently generate vaccines that naturally occur in a certain type of tissue or in a specific structure of the body," said Erik Wallen, M.S., senior research assistant at the UNM School of Medicine.


Story Source:

The above story is based on materials provided by University Of New Mexico. Note: Materials may be edited for content and length.


Cite This Page:

University Of New Mexico. "UNM Health Sciences Center Researchers Develop Method To Stimulate Immune System Response Against Cancer And Infectious Diseases." ScienceDaily. ScienceDaily, 13 March 1998. <www.sciencedaily.com/releases/1998/03/980313024005.htm>.
University Of New Mexico. (1998, March 13). UNM Health Sciences Center Researchers Develop Method To Stimulate Immune System Response Against Cancer And Infectious Diseases. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/1998/03/980313024005.htm
University Of New Mexico. "UNM Health Sciences Center Researchers Develop Method To Stimulate Immune System Response Against Cancer And Infectious Diseases." ScienceDaily. www.sciencedaily.com/releases/1998/03/980313024005.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins