Featured Research

from universities, journals, and other organizations

Influenza Nasal Spray Vaccine Produces Local Antibody Response

Date:
May 3, 1998
Source:
Vanderbilt University Medical Center
Summary:
A recent study presented at the 1998 Society for Pediatrc Research Annual Meeting shows that a nasal spray is more effective then shots for vaccinating against influenza.

A new nasal spray vaccine is being studied that may prove to be an effective way of vaccinating children against influenza. A recent study presented at the 1998 Society for Pediatric Research Annual Meeting shows that children given the new vaccine developed anti-influenza antibodies in their nasal secretions.

Influenza epidemics occur yearly and are an important cause of wintertime respiratory illness throughout the world. Infection rates are highest in young children, often exceeding 40%. A current vaccine is given by intramuscular injection and is not routinely administered to healthy children.

Vaccines work by stimulating the body's immune system to make antibodies against the infectious agent. It is unknown what types of antibodies are most important in protecting against influenza.

"Traditionally, antibodies measured in the blood are used as a marker for protection. However, there is some evidence that antibodies in the nose, where the virus first enters the body, are more important for protection," said Dr. Thomas Boyce, fellow in Pediatric Infectious Diseases at Vanderbilt University Medical Center.

Knowing which types of antibodies the intranasal influenza vaccine stimulates will be important in refining future versions of the vaccine.

"In our study we sought to determine whether the intranasal influenza vaccine causes the production of local antibodies in the nose (mucosal IgA antibodies)," said Boyce.

Researchers at Vanderbilt obtained nasal washes on 19 children before and after they had been given either the intranasal influenza vaccine or a placebo. They then tested the nasal washes for mucosal IgA antibodies to the three different influenza strains contained in the vaccine. The majority of children who had been given the vaccine developed mucosal IgA antibodies to all three influenza strains, whereas most of the children who received placebo did not.

"The nasal spray vaccine appears to stimulate the production of local antibodies in the nose, where influenza enters the body," said Boyce. "We hope these antibodies will stop the virus in its tracks, before it has a chance to spread to the rest of the respiratory system."

Further studies are under way to determine if the presence of these local antibodies correlates with protection from infection with the influenza virus.


Story Source:

The above story is based on materials provided by Vanderbilt University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Vanderbilt University Medical Center. "Influenza Nasal Spray Vaccine Produces Local Antibody Response." ScienceDaily. ScienceDaily, 3 May 1998. <www.sciencedaily.com/releases/1998/04/980423101431.htm>.
Vanderbilt University Medical Center. (1998, May 3). Influenza Nasal Spray Vaccine Produces Local Antibody Response. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/1998/04/980423101431.htm
Vanderbilt University Medical Center. "Influenza Nasal Spray Vaccine Produces Local Antibody Response." ScienceDaily. www.sciencedaily.com/releases/1998/04/980423101431.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins