Featured Research

from universities, journals, and other organizations

New Radiation Procedure Targets Liver Malignancies

Date:
June 4, 1998
Source:
University Of Michigan
Summary:
Research from the University of Michigan Comprehensive Cancer Center suggests patients with advanced liver cancer can tolerate high doses of radiation therapy---which will potentially improve their chances of survival.

ANN ARBOR---Research from the University of Michigan Comprehensive Cancer Center suggests patients with advanced liver cancer can tolerate high doses of radiation therapy---which will potentially improve their chances of survival.

Related Articles


"If you can safely increase the dose of radiation delivered along with chemotherapy, you improve the patient's chance of responding to the therapy. Our prior studies, which involved more than 100 patients, have shown this to be the case," says Cornelius McGinn, M.D., a radiation oncologist and lead investigator on the U-M liver cancer study.

For 10 years, U-M researchers William Ensminger, M.D., Ph.D., Theodore Lawrence, M.D., Ph.D., and Randall Ten Haken, Ph.D., have investigated the use of focal liver irradiation along with chemotherapy delivered directly to the tumor via the hepatic artery. As a result of that research, they have developed a detailed formula for estimating the risk of radiation-induced liver disease for individual patients, based on the volume of normal liver tissue that is irradiated along with cancer cells.

The strategy works, McGinn says, by carefully targeting the tumor with external beam irradiation and excluding as much healthy liver tissue as possible. For each patient a dose is then selected which should maximize the potential benefit of radiation without exceeding an estimated 10 percent chance of developing radiation-induced liver disease.

At this point, 21 patients have been treated this way. The average radiation dose was significantly higher than the dose they would have would have been administered in the previous study, and only one patient has experienced a radiation-related complication. "This is probably the most aggressive non-surgical treatment a patient can receive for liver cancer in this country," McGinn says.

A paper detailing the U-M findings will be published in the June issue of the Journal of Clinical Oncology.

The next phase of the research involves further increasing the radiation dose in an additional group of patients (because the current formula has been found to over-estimate the risk of complications) and studying how much this regimen improves tumor control.


Story Source:

The above story is based on materials provided by University Of Michigan. Note: Materials may be edited for content and length.


Cite This Page:

University Of Michigan. "New Radiation Procedure Targets Liver Malignancies." ScienceDaily. ScienceDaily, 4 June 1998. <www.sciencedaily.com/releases/1998/06/980604071612.htm>.
University Of Michigan. (1998, June 4). New Radiation Procedure Targets Liver Malignancies. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/1998/06/980604071612.htm
University Of Michigan. "New Radiation Procedure Targets Liver Malignancies." ScienceDaily. www.sciencedaily.com/releases/1998/06/980604071612.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins