Featured Research

from universities, journals, and other organizations

Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each

Date:
July 20, 1998
Source:
University Of Chicago Medical Center
Summary:
Adding low doses of angiostatin -- a naturally produced substance that inhibits the formation of new blood vessels -- to standard radiation therapy dramatically improves the response to cancer treatment in animal models without increasing toxicity, report researchers from the University of Chicago Medical Center, Harvard Medical School and Northwestern University.

Adding low doses of angiostatin -- a naturally produced substance that inhibits the formation of new blood vessels -- to standard radiation therapy dramatically improves the response to cancer treatment in animal models without increasing toxicity, report researchers from the University of Chicago Medical Center, Harvard Medical School and Northwestern University in the July 16 issue of Nature.

Human angiostatin alone produced only a modest decrease in tumor growth when given to mice with large tumors. Radiation therapy alone produced a slightly greater response. The combination of angiostatin and radiation, however, caused significant growth inhibition, demonstrating a powerful synergistic effect, even in mice with very large tumors.

"Our finding suggests that radiation therapy, already a standard of cancer care, could be dramatically improved by simultaneous administration of relatively small doses of angiostatin," said Ralph Weichselbaum, M.D., professor and chairman of radiation oncology at the University of Chicago and director of the study.

"This combination could make radiation much more effective at providing local control of cancer, a crucial part of treatment for many tumors, including prostate, brain, head & neck and other cancers. It could even expand the use of radiation therapy to some forms of metastatic disease without requiring high doses."

The researchers also studied the combination of radiation plus mouse angiostatin against human cancers of the brain, head & neck, and prostate that had been transplanted into mice. Once again, the combination was far more effective than the combined effects of each therapy used alone.

For example, in mice with large radiation-resistant human tumors (SQ20-B, a form of head & neck cancer), angiostatin alone reduced the tumor volume 16%, radiation alone reduced volume 18%, but combined therapy reduced the average tumor volume 64%.

Surprisingly, tumors treated with the combined therapy had fewer blood vessels than those treated with angiostatin alone. Radiation kills tumor cells but was not expected to alter tumor blood-vessel formation. Angiostatin inhibits the growth of new blood vessels but has no effect on tumor cells.

When the team performed additional studies, however, looking at the effects of each treatment on the cells that line arteries and veins, they found that angiostatin not only killed some of these endothelial cells, but it also sensitized the survivors to radiation. So the radiation, in combination with angiostatin, enhanced the drug's ability to block the growth of new tumor-supplying blood vessels.

"We were particularly pleased by the manner in which these two agents team up to shrink tumors," said Weichselbaum. Although cancer cells mutate frequently, enabling them to build up radiation resistance, the vessels that feed these tumors are genetically stable and therefore far less likely to develop resistance.

"Angiostatin brings radiation into action against the tumor vasculature in addition to its impact on tumor cells," said Weichselbaum, "which means that resistance is far less likely to develop. This suggests that the combination of treatments may be effective against tumors that were not previously susceptible to radiation therapy."

The researchers were also excited by the remarkably low doses of angiostatin required to have an impact, when combined with radiation -- far less than the effective doses of the drug when used alone.

Since angiostatin is currently in extremely short supply, "clinical trials of low doses used briefly along with radiation to eliminate tumors, rather than higher doses given over sustained periods to prevent new growth, are perhaps the logical next step," advised Weichselbaum.

Additional authors of the paper include Helena Mauceri, Nader Hanna, Michael Beckett, David Gorski, Mary-Jane Staba, Kerri Stellato, Kevin Bigelow and Ruth Heimann from the University of Chicago; Stephen Gately and Gerald Soff from Northwestern; and Mohanraj Dhanabal, Vikas Sukhatme, and Donald Kufe from Harvard.

Funding support came from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University Of Chicago Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Chicago Medical Center. "Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each." ScienceDaily. ScienceDaily, 20 July 1998. <www.sciencedaily.com/releases/1998/07/980720081353.htm>.
University Of Chicago Medical Center. (1998, July 20). Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/1998/07/980720081353.htm
University Of Chicago Medical Center. "Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each." ScienceDaily. www.sciencedaily.com/releases/1998/07/980720081353.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins