Featured Research

from universities, journals, and other organizations

Researchers Develop Animal Model Of Human Colorectal Cancer

Date:
September 18, 1998
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
The development of the first animal model for colorectal cancer by scientists at UT Southwestern Medical Center at Dallas will facilitate research into the molecular mechanisms of colorectal cancer and provide a model system for testing chemoprevention agents and new drug treatments.

DALLAS - September 18, 1998 - The development of the first animal model for colorectal cancer by scientists at UT Southwestern Medical Center at Dallas will facilitate research into the molecular mechanisms of colorectal cancer and provide a model system for testing chemoprevention agents and new drug treatments.

One in every 20 Americans will get colorectal cancer, the second-leading cause of cancer deaths. The collaborative work of Drs. Jon Graff, Luis Parada and colleagues, published in today's issue of Cell, could dramatically change that prospect. Initially the researchers will use their colon cancer mouse model, which mimics the human disease in many aspects, to look at ways of preventing cancer.

"The real strength of the model is that we can use the power of modern molecular biology to alter the genetic background and look at colorectal cancer in a very specific and fundamental way," said Graff, assistant professor in UT Southwestern's Center for Developmental Biology. "We want to do pharmacological and genetic manipulations with the idea that we can use the two as a synergistic approach to really get to the basis of prevention."

The investigators were able to induce colon cancer in all of the tested mice by altering a single gene, Smad3, which belongs to a gene family known to be involved in conveying signals from the cell's surface to the cell's nucleus. Smad genes also have been characterized as tumor- suppressor genes.

"My student, Yuan Zhu, chose to look at the Smad3 gene because of previous work by Dr. Graff and because the Smad gene family conveys signals from type II transforming growth factor - (TGF b [beta]). TGF b [beta] mutations are seen in some types of hereditary and sporadic colon cancer," said Dr. Luis Parada, director of the Center for Developmental Biology, holder of the Diana K. and Richard C. Strauss Chair in Developmental Biology and director of the Kent Waldrep Foundation Center for Basic Neuroscience. "In mice, previous research had indicated that alterations in other genes of the Smad family did not lead to colon cancer."

The scientists genetically inactivated the Smad3 gene to produce mice with no Smad3 gene function. They showed conclusively that the normal Smad3 gene functions as a powerful suppressor of colorectal cancer. With this cancer suppressor inactivated, mice spontaneously developed multistage colorectal cancer that had many parallels to the human disease including metastasis to lymph nodes.

As of today, no Smad3 mutations have been found in human cases of colorectal cancer. But Graff believes that since Smad2 and Smad3 are almost identical in structure, the role of Smad3 in the mouse may be analogous to the human Smad2, which has been found in a mutated state in a subset of human colorectal cancers.

"For me the joy would be to help patients and ultimately to cure this illness," Graff said.

Other UT Southwestern scientists participating in this project were first author Yuan Zhu, a doctoral student in the Center for Developmental Biology, and Dr. James Richardson, associate professor of pathology.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Researchers Develop Animal Model Of Human Colorectal Cancer." ScienceDaily. ScienceDaily, 18 September 1998. <www.sciencedaily.com/releases/1998/09/980918070755.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1998, September 18). Researchers Develop Animal Model Of Human Colorectal Cancer. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1998/09/980918070755.htm
University Of Texas Southwestern Medical Center At Dallas. "Researchers Develop Animal Model Of Human Colorectal Cancer." ScienceDaily. www.sciencedaily.com/releases/1998/09/980918070755.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins