Featured Research

from universities, journals, and other organizations

'DES Daughters' Had Increased Rates Of Cancer; An Animal Study Shows 'DES Granddaughters' May Too

Date:
September 28, 1998
Source:
NIH-National Institute Of Environmental Health Sciences
Summary:
Like 'DES daughters,' DES granddaughters may have an increased risk of reproductive tract cancers, an animal study published today suggests. DES, or diethylstilbestrol, is the synthetic estrogen once used in attempts to treat women at risk for miscarriage.

Like 'DES daughters,' DES granddaughters may have an increased risk of reproductive tract cancers, an animal study published today suggests.

DES, or diethylstilbestrol, is the synthetic estrogen once used in attempts to treat women at risk for miscarriage.

Now, scientists at the National Institute of Environmental Health Sciences report that they have observed an increase in cancers, including cancer of the uterus, in female mice whose mothers were exposed to DES in utero -- while in the uterus. The subsequent generation of female mice reported today was not exposed to DES.

While both generations had increased reproductive tract cancers, fertility was impaired only in the female mice exposed to DES in utero (the 'DES daughters') but not in their unexposed female offspring (the 'DES granddaughters'), the scientists said.

The study was reported today in the scientific journal Carcinogenesis (September, pp. 1655-1663) by Retha R. Newbold, Rita B. Hanson and Wendy N. Jefferson, all of NIEHS; Bill C. Bullock of the Bowman-Gray School of Medicine at Wake Forest University, Winston-Salem, N.C.; Joseph Haseman of NIEHS, and John A. McLachlan of Tulane/Xavier Center for Bioenvironmental Research, Tulane University, New Orleans.

Newbold and her colleagues said "the data suggest transmission of susceptibility of genital tract cancers to subsequent generations." They said this concept is supported by results in male mouse siblings in which like the females described in this study, reproduction is not affected but rare cancers are observed. A report on the effects in males is being completed, Newbold said.

Newbold and her colleagues said that although additional study of risks from environmental agents are needed, the findings "indicate that the cascade of events that lead to the appearance of a tumor may well begin before birth and perhaps before conception."

For more than 20 years, beginning in the 1940s, DES was commonly prescribed to pregnant women to prevent miscarriages, but the practice was abandoned after 1971 when investigators found an extremely rare reproductive tract tumor, vaginal adenocarcinoma, in the young daughters of the treated women. Although the incidence of cancer was ultimately determined to be low, other abnormalities, including poor reproductive outcome in DES daughters, are quite common.

Other well-known uses of DES, such as to fatten cattle and chickens, have also been discontinued.

###

Carcinogenesis is available on the Web at http://www.oup.co.uk/carcin


Story Source:

The above story is based on materials provided by NIH-National Institute Of Environmental Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

NIH-National Institute Of Environmental Health Sciences. "'DES Daughters' Had Increased Rates Of Cancer; An Animal Study Shows 'DES Granddaughters' May Too." ScienceDaily. ScienceDaily, 28 September 1998. <www.sciencedaily.com/releases/1998/09/980928072328.htm>.
NIH-National Institute Of Environmental Health Sciences. (1998, September 28). 'DES Daughters' Had Increased Rates Of Cancer; An Animal Study Shows 'DES Granddaughters' May Too. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1998/09/980928072328.htm
NIH-National Institute Of Environmental Health Sciences. "'DES Daughters' Had Increased Rates Of Cancer; An Animal Study Shows 'DES Granddaughters' May Too." ScienceDaily. www.sciencedaily.com/releases/1998/09/980928072328.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins