Featured Research

from universities, journals, and other organizations

Scientists Discover How Aspirin Reduces Inflammation

Date:
November 5, 1998
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
Everyone knows that aspirin helps reduce inflammation, but for years no one knew how. Researchers at UT Southwestern Medical Center at Dallas now have an answer, which could lead to the design of more effective anti-inflammatory drugs.

DALLAS - November 5, 1998 - Everyone knows that aspirin helps reduce inflammation, but for years no one knew how. Researchers at UT Southwestern Medical Center at Dallas now have an answer, which could lead to the design of more effective anti-inflammatory drugs.

Related Articles


Dr. Richard Gaynor, interim director of the Harold C. Simmons Comprehensive Cancer Center and professor of internal medicine, and colleagues describe the molecular action of aspirin and salicylate (from which aspirin is derived) in the Nov. 5 issue of the journal Nature.

Inflammation occurs due to a complex series of responses, many of which have been known for the last decade. Some of the initial steps take place within the nucleus of the cell where "gene regulators" switch on the production of specific genes, which in turn act on other genes causing a cascade of events leading to inflammation.

One of the initiators in this inflammatory cascade, a cellular protein called NF-kB, is inactive until it gets into the nucleus where it turns on genes involved in the inflammatory response. The gatekeeper or inhibitor of NF-kB is another protein, IkB, which if destroyed frees up NF-kB to enter the nucleus and start the inflammatory process.

"This work suggests that one of the critical cellular proteins that aspirin targets to inhibit inflammation is a kinase that activates the NF-kB pathway. Since NF-kB is a critical inducer of cellular genes involved in the inflammatory process, aspirin inhibition of this kinase prevents NF-kB activation and suppresses inflammation," Gaynor said. "This kinase is an excellent target for the development of novel anti-inflammatory agents."

In this paper Gaynor and colleagues clearly define a molecular step where aspirin and salicylate act to block the inflammatory cascade -- they inhibit one of the proteins involved in the destruction of IkB. The result is that NF-kB remains sequestered outside the cell's nucleus thereby preventing the NF-kB-induced inflammatory response. This process, in addition to the inhibition of inflammatory mediators known as prostaglandins, likely explains many of aspirin's inflammation-reducing effects.

Other UT Southwestern co-authors were internal medicine research fellow Min-Jean Yin and research assistant Yumi Yamamoto. Gaynor, who holds the Andrea L. Simmons Distinguished Chair in Cancer Virology, is chief of hematology-oncology at UT Southwestern.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Scientists Discover How Aspirin Reduces Inflammation." ScienceDaily. ScienceDaily, 5 November 1998. <www.sciencedaily.com/releases/1998/11/981105065817.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1998, November 5). Scientists Discover How Aspirin Reduces Inflammation. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/1998/11/981105065817.htm
University Of Texas Southwestern Medical Center At Dallas. "Scientists Discover How Aspirin Reduces Inflammation." ScienceDaily. www.sciencedaily.com/releases/1998/11/981105065817.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins