Featured Research

from universities, journals, and other organizations

USC Scientists Identify Enzyme Important In Short-Term Memory

Date:
November 13, 1998
Source:
University Of Southern California
Summary:
An enzyme that fails to get activated in patients with Alzheimer's disease may play a broader role in normal memory, report USC neuroscientists Zoltan Tokes, Ph.D., and Giselle Lim, Ph.D., at the meeting of the Society for Neuroscience in Los Angeles.

An enzyme that fails to get activated in patients with Alzheimer's disease may play a broader role in normal memory, report USC neuroscientists Zoltan Tokes, Ph.D., and Giselle Lim, Ph.D., at the meeting of the Society for Neuroscience in Los Angeles today.

In 1996, Tokes showed that an enzyme produced by neurons in the hippocampus, a region of the brain important in short term memory and learning, was inactive in Alzheimer's patients.

The inactivity of the enzyme persisted despite a greater amount of the enzyme, called matrix metalloproteinase-9 or MMP-9, being produced in the neurons of people with Alzheimer's. In healthy brains, investigators believe MMP-9 acts to help digest and clear away proteins that may accumulate around the nerve cells and interfere with their function.

The team hypothesized that the inactive MMP-9 found in Alzheimer's patients might explain the build-up of characteristic protein plaques found in these patients. Now, Tokes and colleagues say that the inactivated enzyme might also explain the loss of memory seen in Alzheimer's patients.

Tokes' collaborators, cancer researchers Zena Werb and Tienna Vu at U.C. San Francisco, created a transgenic mouse that was missing a gene for the MMP-9 enzyme. Using a standard memory assay, Tokes and Lim then showed that the "knockout" mice had impaired memory. The finding supports the USC team's idea that inactivity of the MMP-9 enzyme may contribute to the memory impairment seen in patients with Alzheimer's.


Story Source:

The above story is based on materials provided by University Of Southern California. Note: Materials may be edited for content and length.


Cite This Page:

University Of Southern California. "USC Scientists Identify Enzyme Important In Short-Term Memory." ScienceDaily. ScienceDaily, 13 November 1998. <www.sciencedaily.com/releases/1998/11/981113082104.htm>.
University Of Southern California. (1998, November 13). USC Scientists Identify Enzyme Important In Short-Term Memory. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/1998/11/981113082104.htm
University Of Southern California. "USC Scientists Identify Enzyme Important In Short-Term Memory." ScienceDaily. www.sciencedaily.com/releases/1998/11/981113082104.htm (accessed July 29, 2014).

Share This




More Mind & Brain News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins