Featured Research

from universities, journals, and other organizations

Chopping And Cooking Affect Garlic's Anti-Cancer Activity

Date:
November 17, 1998
Source:
Penn State
Summary:
Penn State researchers have shown that microwave heating or roasting garlic can diminish or destroy its anti-cancer activity - unless the herb is chopped or crushed, and allowed to "stand" for at least 10 minutes before cooking.

University Park, Pa. --- Penn State researchers have shown that microwave heating or roasting garlic can diminish or destroy its anti-cancer activity - unless the herb is chopped or crushed, and allowed to "stand" for at least 10 minutes before cooking.

Kun Song, doctoral candidate in nutrition, and Dr. John A. Milner, professor and head of the Department of Nutrition, conducted the study.

The research was the first to show that as little as one minute of microwaving or 45 minutes of oven roasting can completely block garlic's ability to retard the action of a known cancer-causing agent in rats. Garlic's anti-cancer activity was retained, however, if the herb was first chopped or crushed and allowed to stand for 10 minutes before being heated. In the case of roasted whole garlic, anti-cancer activity was partially retained if the top of the bulb was sliced off prior to heating.

Song presented the results in a poster session titled, "Heating Blocks Garlic's Protection Against 7,12 Dimethylbenz(a)anthrancene (DMBA) Induced Rat Mammary DNA Adducts," at a conference on "Recent Advances on the Nutritional Benefits Accompanying the Use of Garlic as a Supplement" at the Marriott Newport Center, Newport Beach, Calif.

The conference is a continuing and distance education service of the Penn State College of Health and Human Development Department of Nutrition in cooperation with Wakunaga of America Co. Ltd. The conference is supported by Wakunaga, National Cancer Institute and Rexall-Sundown Inc.

In a recent interview, Song said that the 10-minute "standing period" after chopping or crushing the garlic enables an enzyme naturally present in certain garlic cells to come in contact with and act on chemicals in other cells. Chopping or crushing the garlic opens the cells and enables the enzyme to start a reaction that produces chemicals called allyl sulfur compounds that possess anti-cancer properties.

"The allyl sulfur compounds produced from the enzyme's reaction are critical to garlic's anti-cancer effects," Song noted. "If garlic was heated or roasted immediately after crushing, the enzyme was de-activated by the heating process and garlic's anti-cancer effects were blocked."

Song and Milner conducted the study with rats given garlic by intubation six times over a two-week period. The rats received garlic equal to 2 percent of their daily food ration. After the feeding period was over, the rats were treated with a breast tumor inducer called DMBA. Genetic material (DNA) from the rats' breast tissue then was examined in order to count the number of instances in which DMBA reaction products or metabolites had become attached to the DNA. The number of DMBA metabolites binding to DNA, called DNA adducts, was used as the measure of cancer incidence.

Rats that received no garlic had the highest number of adducts. Rats given raw garlic showed an average decrease of 64 percent in adduct formation compared with rats that had received no garlic. Rats given garlic that had been heated for one minute in the microwave oven or roasted in a convention oven for 45 minutes after being crushed and allowed to "stand" for 10 minutes showed 41 percent and 21 percent reductions in adduct formation, respectively. Rats given heated or roasted garlic that had not been allowed to stand showed no decrease in adducts compared with non-garlic fed rats.

The study was supported by a grant from the American Institute of Cancer Research.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Cite This Page:

Penn State. "Chopping And Cooking Affect Garlic's Anti-Cancer Activity." ScienceDaily. ScienceDaily, 17 November 1998. <www.sciencedaily.com/releases/1998/11/981117075803.htm>.
Penn State. (1998, November 17). Chopping And Cooking Affect Garlic's Anti-Cancer Activity. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/1998/11/981117075803.htm
Penn State. "Chopping And Cooking Affect Garlic's Anti-Cancer Activity." ScienceDaily. www.sciencedaily.com/releases/1998/11/981117075803.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins