NYU Scientists Build Nano-Robotic "Arm" Prototype From Synthetic DNA

The research team was led by NYU chemistry professor Nadrian C. Seeman. Their findings are reported in the January 14, 1999 issue of Nature. Seeman said, "Using synthetic DNA as a building material, we have constructed a controllable molecular mechanical system. In the short-run, this is an exciting technical achievement. In the long-term, the work will have implications for the development of nano-scale robots and for molecular manufacturing."

The specificity of base-pairing allows strands of DNA to be 'programmed' to self assemble in well-defined ways. Seeman's team took advantage of this fact. The device was constructed by fusing together two synthetic "double-crossover" (DX) DNA molecules. They are joined by a bridge containing the classical right-handed DNA structure called B-DNA.

These findings are reported in a letter to Nature entitled "A Nanomechanical Device Based on the B-Z Transition of DNA." The authors are as follows: Chengde Mao, Weiqiong Sun, Zhiyon Shen and Nadrian C. Seeman.

Nadrian C. Seeman was born in Chicago in 1945. Following a BS in biochemistry from the University of Chicago, he received his Ph.D. in biological crystallography from the University of Pittsburgh in 1970. His postdoctoral training, at Columbia and MIT, emphasized nucleic acid crystallography. He has received numerous awards for his work on developing ways to construct three-dimensional objects, including cubes and more complex polyhedra, from synthetic DNA molecules. In August, 1998, he reported in Nature that his lab had developed a reliable technique for arranging DNA molecules into two-dimensional crystals.