Featured Research

from universities, journals, and other organizations

UCSF Researchers Identify Key Genes In Bone Healing Process That Could Lead To New, Molecular-Based Treatments

Date:
February 10, 1999
Source:
University Of California, San Francisco
Summary:
Researchers from the University of California San Francisco studying bone healing in animal models have found that two genes essential for bone formation in the fetus are also key to successful fracture repair in the adult. Through a clever biologic regulatory process, the two genes become inactive when fetal development concludes but then resurface when needed to help mend broken bones.

Anaheim, Calif. -- Researchers from the University of California San Francisco studying bone healing in animal models have found that two genes essential for bone formation in the fetus are also key to successful fracture repair in the adult.

Through a clever biologic regulatory process, the two genes become inactive when fetal development concludes but then resurface when needed to help mend broken bones.

"These findings shed new light on the bone formation process at the molecular level. Now we can use these principles to begin to develop new clinical treatments for troublesome fractures in which we mimic the natural healing process," said Theodore Miclau, MD, lead investigator and UCSF assistant professor of orthopaedic surgery who treats patients at San Francisco General Hospital Medical Center.

Miclau presented the study findings here today (February 5) at the annual meeting of the American Academy of Orthopaedic Surgeons. Working with adult mice, the UCSF team focused on the expression patterns of two embryonic genes, cbfal and Indian hedgehog, which are known to be indispensable in fetal bone formation.

Study results showed the genes reappeared in the bone of a mature animal when it underwent a fracture. During this process of "reinduction," the genes activated the expression of two proteins that contributed to bone healing in the adult model in a sequence very similar to the pattern that takes place during skeletal formation in the fetus.

The researchers analyzed bone tissue at the fracture site in adult mice at 3, 6, 8, 10, and 14 days after fracture to assess the presence of growth factors and other proteins. The UCSF team is believed to be the first to report the expression of the two genes in an animal bone repair model.

"Understanding this cascade of events and the specific growth factors involved in bone repair is a small step but a significant one. If we can replicate the pattern and target therapy directly to the fracture site through injection, there is potential for greatly improving our ability to treat a bone healing problem," Miclau said.

This type of targeted, molecular-based treatment would be more desirable than a bone graft, which currently is the most common therapy for a problem fracture, according to Miclau. A graft involves taking bone from elsewhere in the body, usually the pelvis, and carries an overall complication rate of about 25 percent. Ten years from now, Miclau foresees targeted therapy replacing the majority of bone graft procedures.

The UCSF study team represents a collaboration of clinicians with basic scientists. Miclau, a surgeon, headed the research project with Jill Helms, DDS, PhD, director of the Molecular and Cellular Biology Laboratory of the UCSF Department of Orthopaedic Surgery. Eytan Alpern, MD, UCSF research fellow in orthopaedic surgery, and Cristin Ferguson, MD, University of Rochester, contributed to the project.

The study was funded by grants from the Orthopaedic Research and Education Foundation and the Orthopaedic Trauma Association.


Story Source:

The above story is based on materials provided by University Of California, San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, San Francisco. "UCSF Researchers Identify Key Genes In Bone Healing Process That Could Lead To New, Molecular-Based Treatments." ScienceDaily. ScienceDaily, 10 February 1999. <www.sciencedaily.com/releases/1999/02/990210070313.htm>.
University Of California, San Francisco. (1999, February 10). UCSF Researchers Identify Key Genes In Bone Healing Process That Could Lead To New, Molecular-Based Treatments. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/1999/02/990210070313.htm
University Of California, San Francisco. "UCSF Researchers Identify Key Genes In Bone Healing Process That Could Lead To New, Molecular-Based Treatments." ScienceDaily. www.sciencedaily.com/releases/1999/02/990210070313.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins