Featured Research

from universities, journals, and other organizations

Multicomponent Malaria Vaccine Shows Promise In Laboratory Tests

Date:
February 17, 1999
Source:
National Institute Of Allergy And Infectious Diseases
Summary:
A team of researchers, including grantees of the National Institute of Allergy and Infectious Diseases, today reported positive results of research on a new, broad-based malaria vaccine. A paper describing their findings appears in the February 16 issue of the Proceedings of the National Academy of Sciences USA.

A team of researchers, including grantees of the National Institute of Allergy and Infectious Diseases (NIAID), today reported positive results of research on a new, broad-based malaria vaccine. A paper describing their findings appears in the February 16 issue of the Proceedings of the National Academy of Sciences USA.

Health officials have long sought a vaccine to prevent malaria, a disease that affects 300 to 500 million people and kills up to 3 million people worldwide each year. "Improving international health is a high priority of the NIAID, and malaria research is a major area of interest," comments Anthony S. Fauci, M.D., director of the institute. "Although these results are preliminary and the candidate vaccine has yet to be tested in people, its effectiveness in laboratory tests makes it an interesting candidate for further study."

The most severe form of malaria is caused by a microscopic parasite, Plasmodium falciparum, that is transmitted to humans by mosquitoes. The parasite has a complex life cycle. Following injection into the bloodstream, it rapidly travels to the liver where it multiplies. New forms of the parasite are then released into the bloodstream where they invade red blood cells, ultimately destroying them. In their recent paper, a research team directed by Altaf A. Lal, Ph.D., of the U.S. Centers for Disease Control and Prevention (CDC), describes a new candidate vaccine that targets the malaria parasite at several stages of its life cycle.

The scientists combined segments of 21 different P. falciparum proteins to form a single recombinant protein, which they used to immunize rabbits. Each of the 21 segments, or peptides, was selected because it was recognized by the immune systems of people with malaria, as shown in earlier studies. Furthermore, the peptides targeted different branches of the immune system: B cells, helper T cells and cytotoxic T lymphocytes (CTLs).

Laboratory tests showed that the vaccine induced a high level of antibodies that recognized the parasite at different stages of development. The antibodies also blocked P. falciparum invasion into the rabbits' liver cells and inhibited growth of the organism in their blood. Although the researchers have not yet looked at the T-cell responses in vaccinated animals, these studies are under way.

"Multicomponent vaccines may offer an advantage over single-component vaccines because they may provide multiple levels of protection against different parasite stages," says Lee Hall, M.D., Ph.D., program officer for parasite vaccine development at NIAID. "Such vaccines may also reduce the spread of vaccine-resistant strains, which can arise when a pathogen changes a surface protein to avoid detection by the immune system."

NIAID is a component of the National Institutes of Health (NIH). NIAID conducts and supports research to prevent, diagnose and treat illnesses such as HIV disease and other sexually transmitted diseases, tuberculosis, malaria, asthma and allergies. NIH is an agency of the U.S. Department of Health and Human Services.

###

Reference: Y Ping Shi, et al. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine. Proc Natl Acad Sci USA 96:1615-20 (1999).

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.


Story Source:

The above story is based on materials provided by National Institute Of Allergy And Infectious Diseases. Note: Materials may be edited for content and length.


Cite This Page:

National Institute Of Allergy And Infectious Diseases. "Multicomponent Malaria Vaccine Shows Promise In Laboratory Tests." ScienceDaily. ScienceDaily, 17 February 1999. <www.sciencedaily.com/releases/1999/02/990216160106.htm>.
National Institute Of Allergy And Infectious Diseases. (1999, February 17). Multicomponent Malaria Vaccine Shows Promise In Laboratory Tests. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/1999/02/990216160106.htm
National Institute Of Allergy And Infectious Diseases. "Multicomponent Malaria Vaccine Shows Promise In Laboratory Tests." ScienceDaily. www.sciencedaily.com/releases/1999/02/990216160106.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins