Featured Research

from universities, journals, and other organizations

Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment

Date:
February 19, 1999
Source:
Wistar Institute
Summary:
Farnesyltransferase inhibitors (FTIs) are a relatively new class of nontoxic chemotherapeutic drugs that have an ability to target mutated oncogenes while bypassing normal cells; i.e., they may be the long sought-after magic bullet in cancer treatment. In pre-clinical studies, FTIs have proven to control the growth of cancer cells and promote tumor regression. Little has been known, however, about how and why they work.

Farnesyltransferase inhibitors (FTIs) are a relatively new class of nontoxic chemotherapeutic drugs that have an ability to target mutated oncogenes while bypassing normal cells; i.e., they may be the long sought-after magic bullet in cancer treatment.

Related Articles


In pre-clinical studies, FTIs have proven to control the growth of cancer cells and promote tumor regression. Little has been known, however, about how and why they work.

From their recent studies of FTIs, Wistar scientist, George Prendergast, Ph.D., and his Wistar research team made some surprising discoveries about their mechanism of action. Their findings appear today in the March issue of the scientific journal, Molecular and Cellular Biology.

The Wistar scientists had expected FTIs to interfere in some way with the activity of RAS, a cancer protein that tells cells when to start and stop dividing. Instead, they found that FTIs act in large part by affecting RHO, a class of proteins that regulate cell shape, survival and motility. Since RHO levels are elevated in many metastatic tumors, scientists have suspected for some time that RHO and cancer are in some way related. They had not known, however, if their relationship was causative or correlative.

One significant and unexpected finding of the study was that FTIs activate features of RHO by stimulating the production of an isoform with altered properties in the cell. In this way, FTIs make it possible for RHO to perform activities it could not previously perform.

An understanding of RHO alteration as the tumor principle targeted by FTIs will make it possible to make FTIs more effective, avoid drug resistance problems, and design other types of nontoxic antitumor drugs that target the same principle.

###

The Wistar Institute, established in 1892, was the first independent medical research facility in the country. For more than 100 years, Wistar scientists have been making history and improving world health through their development of vaccines for diseases that include rabies, German measles, infantile gastroenteritis (rotavirus), and cytomegalovirus; discovery of molecules like interleukin-12, which are helping the immune system fight bacteria, parasites, viruses and cancer; and location of genes that contribute to the development of diseases like breast, lung and prostate cancer. Wistar is a National Cancer Institute Cancer Center.


Story Source:

The above story is based on materials provided by Wistar Institute. Note: Materials may be edited for content and length.


Cite This Page:

Wistar Institute. "Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment." ScienceDaily. ScienceDaily, 19 February 1999. <www.sciencedaily.com/releases/1999/02/990219080918.htm>.
Wistar Institute. (1999, February 19). Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/1999/02/990219080918.htm
Wistar Institute. "Wistar Scientists Define Mechanism Of Action Used By Potential Magic Bullet In Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/1999/02/990219080918.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins