Featured Research

from universities, journals, and other organizations

New Strategy May Succeed At Extending The Life Of Transplanted Kidneys

Date:
May 19, 1999
Source:
University Of Maryland Medical Center
Summary:
A kidney transplant offers people with kidney failure a new chance at a normal, active life. But, on average, a transplanted kidney continues to function for only nine years. Now, doctors at the University of Maryland Medical Center say a new strategy to extend the function of transplanted kidneys shows promise.

A kidney transplant offers people with kidney failure a new chance at a normal, active life. But, on average, a transplanted kidney continues to function for only nine years. Now, doctors at the University of Maryland Medical Center say a new strategy to extend the function of transplanted kidneys shows promise.

Related Articles


In a study of 60 people who had received kidney transplants and were showing signs of kidney deterioration, University of Maryland researchers found that they could improve the kidney function in the majority of patients by cutting in half the dose of cyclosporine (Neoral), a widely used drug to prevent rejection, and adding a new anti-rejection drug mycophenolate mofetil (CellCept). The findings will be presented at the American Society of Transplantation meeting in Chicago on May 16.

Although both drugs prevent the body's rejection of the new kidney by suppressing the patient's immune system, they work in different ways, and therefore may have a different effect on transplanted kidneys over time. "Many kidney transplant patients, especially those whose kidneys came from cadaver donors, experience a slow but steady deterioration of function of their new kidney. Before, we had no proven way to intervene. We have been trying to develop new strategies to prevent kidney dysfunction or at least slow it down," says Matthew Weir, M.D., professor of medicine and head of the division of Nephrology at the University of Maryland School of Medicine.

"We are encouraged that with our new strategy, we saw an improvement in kidney function in 37 of the patients we studied, over an average time span of two years after starting the new drug combination. It means we can have an impact," adds Dr. Weir.

After an organ transplant, all patients need to take medications the rest of their lives to prevent their body's immune system from attacking the new organ and destroying it. However, these anti-rejection drugs can also cause side effects and impair the functioning of the new kidney over time. Other factors that threaten the long-term functioning of a new kidney include high blood pressure and high glucose and cholesterol levels.

Dr. Weir says careful monitoring and follow up are needed for all kidney transplant recipients, so that adjustments can be made in medication. Changes in kidney function are subtle and can only be detected at an early stage with urine and blood tests.

Members of the University of Maryland Medical Center transplant team are so encouraged by their findings that the new therapeutic strategy is being used in all kidney transplant patients who experience erosion of their kidney function. The study was funded in part by Hoffman-La Roche, Inc., which makes CellCept. The University of Maryland Medical Center has the second busiest kidney transplant program in the U.S.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "New Strategy May Succeed At Extending The Life Of Transplanted Kidneys." ScienceDaily. ScienceDaily, 19 May 1999. <www.sciencedaily.com/releases/1999/05/990519065048.htm>.
University Of Maryland Medical Center. (1999, May 19). New Strategy May Succeed At Extending The Life Of Transplanted Kidneys. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/1999/05/990519065048.htm
University Of Maryland Medical Center. "New Strategy May Succeed At Extending The Life Of Transplanted Kidneys." ScienceDaily. www.sciencedaily.com/releases/1999/05/990519065048.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins