Featured Research

from universities, journals, and other organizations

New Strategy May Succeed At Extending The Life Of Transplanted Kidneys

Date:
May 19, 1999
Source:
University Of Maryland Medical Center
Summary:
A kidney transplant offers people with kidney failure a new chance at a normal, active life. But, on average, a transplanted kidney continues to function for only nine years. Now, doctors at the University of Maryland Medical Center say a new strategy to extend the function of transplanted kidneys shows promise.

A kidney transplant offers people with kidney failure a new chance at a normal, active life. But, on average, a transplanted kidney continues to function for only nine years. Now, doctors at the University of Maryland Medical Center say a new strategy to extend the function of transplanted kidneys shows promise.

In a study of 60 people who had received kidney transplants and were showing signs of kidney deterioration, University of Maryland researchers found that they could improve the kidney function in the majority of patients by cutting in half the dose of cyclosporine (Neoral), a widely used drug to prevent rejection, and adding a new anti-rejection drug mycophenolate mofetil (CellCept). The findings will be presented at the American Society of Transplantation meeting in Chicago on May 16.

Although both drugs prevent the body's rejection of the new kidney by suppressing the patient's immune system, they work in different ways, and therefore may have a different effect on transplanted kidneys over time. "Many kidney transplant patients, especially those whose kidneys came from cadaver donors, experience a slow but steady deterioration of function of their new kidney. Before, we had no proven way to intervene. We have been trying to develop new strategies to prevent kidney dysfunction or at least slow it down," says Matthew Weir, M.D., professor of medicine and head of the division of Nephrology at the University of Maryland School of Medicine.

"We are encouraged that with our new strategy, we saw an improvement in kidney function in 37 of the patients we studied, over an average time span of two years after starting the new drug combination. It means we can have an impact," adds Dr. Weir.

After an organ transplant, all patients need to take medications the rest of their lives to prevent their body's immune system from attacking the new organ and destroying it. However, these anti-rejection drugs can also cause side effects and impair the functioning of the new kidney over time. Other factors that threaten the long-term functioning of a new kidney include high blood pressure and high glucose and cholesterol levels.

Dr. Weir says careful monitoring and follow up are needed for all kidney transplant recipients, so that adjustments can be made in medication. Changes in kidney function are subtle and can only be detected at an early stage with urine and blood tests.

Members of the University of Maryland Medical Center transplant team are so encouraged by their findings that the new therapeutic strategy is being used in all kidney transplant patients who experience erosion of their kidney function. The study was funded in part by Hoffman-La Roche, Inc., which makes CellCept. The University of Maryland Medical Center has the second busiest kidney transplant program in the U.S.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "New Strategy May Succeed At Extending The Life Of Transplanted Kidneys." ScienceDaily. ScienceDaily, 19 May 1999. <www.sciencedaily.com/releases/1999/05/990519065048.htm>.
University Of Maryland Medical Center. (1999, May 19). New Strategy May Succeed At Extending The Life Of Transplanted Kidneys. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/1999/05/990519065048.htm
University Of Maryland Medical Center. "New Strategy May Succeed At Extending The Life Of Transplanted Kidneys." ScienceDaily. www.sciencedaily.com/releases/1999/05/990519065048.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins