Featured Research

from universities, journals, and other organizations

New Concepts Proposed To Investigate Drug Reactions

Date:
May 28, 1999
Source:
University Of Toronto
Summary:
A University of Toronto professor says the leading theory on the cause of adverse drug reactions -- that the drug irreversibly binds to proteins or other large molecules which are then perceived as foreign and induce an immune response -- doesn't explain many of the key features of such reactions, including why the response only produces symptoms in some people.

A University of Toronto professor is proposing two new concepts to help better understand the cause of adverse drug reactions.

Related Articles


Jack Uetrecht of the Faculty of Pharmacy says that the leading theory on the cause of these reactions -- that the drug irreversibly binds to proteins or other large molecules which are then perceived as foreign and induce an immune response -- doesn't explain many of the key features of such reactions, including why the response only produces symptoms in some people.

He suggests that researchers consider the "danger hypothesis," which states that the immune system only responds to foreign substances if they appear to cause some sort of damage leading to a danger signal, rather than sticking to the traditional view that the immune system will attack anything foreign. Uetrecht says that researchers should also look at the innate immune system and not just focus on the more specific adaptive immune system. The innate system, which is associated with more primitive organisms but also present in humans, doesn't produce antibodies to foreign substances so if a drug causes cell damage it could provoke a response without leaving any of the evidence that researchers usually associate with an immune response.

"These concepts have the potential to lead to a better understanding of hypersensitivity reactions which in turn could lead to the development of tests to predict which drugs will be associated with such reactions, and as well which patients are likely to react to particular drugs," says Uetrecht.

The research, which was supported by the Medical Research Council of Canada, is published in the May issue of Chemical Research in Toxicology.

CONTACT: Kerry Delaney
U of T Public Affairs
(416) 978-5948
e-mail: kerry.delaney@utoronto.ca


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "New Concepts Proposed To Investigate Drug Reactions." ScienceDaily. ScienceDaily, 28 May 1999. <www.sciencedaily.com/releases/1999/05/990527153303.htm>.
University Of Toronto. (1999, May 28). New Concepts Proposed To Investigate Drug Reactions. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/1999/05/990527153303.htm
University Of Toronto. "New Concepts Proposed To Investigate Drug Reactions." ScienceDaily. www.sciencedaily.com/releases/1999/05/990527153303.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins