Featured Research

from universities, journals, and other organizations

New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments

Date:
July 20, 1999
Source:
University Of Pennsylvania Medical Center
Summary:
Researchers at the University of Pennsylvania Medical Center have devised a safer, more effective strategy for bone marrow transplantation that does not require the use of drugs that globally suppress the immune system.

Researchers at the University of Pennsylvania Medical Center have devised a safer, more effective strategy for bone marrow transplantation that does not require the use of drugs that globally suppress the immune system. A report on the new technique, demonstrated in mice, appears in the July 16 issue of Science.

Related Articles


Transplantation of bone marrow, which gives rise to all types of blood cells in the body, including immune system cells, is useful in treating cancers of the blood and inherited blood disorders. Because it is the source of the cells that constitute the immune system, however, bone marrow transplantation sometimes leads to a potentially quite serious condition called graft-versus-host disease, or GVHD, in which T cells produced by the donor marrow attack the host, i.e., the patient receiving the transplant.

For this reason, powerful drugs that suppress the immune system, primarily by paralyzing T cells, are given to bone marrow transplant recipients to control GVHD. Immune suppression carries its own costs, however, leaving the patient vulnerable to infections and other problems.

The new approach used by the Penn scientists involves inactivating a subset of immune-system cells in the transplant recipient called antigen-presenting cells, or APCs. Although the patient's existing bone marrow is destroyed prior to transplantation - largely to preclude GVHD - APCs originating from that marrow continue to circulate in the patient's blood. Those APCs serve as the trigger for T cells produced by the newly received bone marrow to attack cells in the patient. When these APCs were disabled, however, GVHD was entirely prevented.

"Most techniques for immunosuppression are based upon paralyzing T cells," says Stephen G. Emerson, MD, chief of the division of hematology-oncology, professor of medicine, and senior author on the report. "They're global, and they have serious limitations. Targeting antigen-presenting cells, however, provides a different cell type to focus on for immunosuppression, with the idea of inhibiting host antigen presentation and stopping the process of immune stimulation right at the beginning."

The lead author on the report is Warren D. Shlomchik. The other Penn-based authors are Matthew S. Couzens and Cheng Bi Tang. The coauthors affiliated with Yale University are Jennifer McNiff, Marie E. Robert, Jinli Liu, and Mark J. Shlomchik.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments." ScienceDaily. ScienceDaily, 20 July 1999. <www.sciencedaily.com/releases/1999/07/990720083803.htm>.
University Of Pennsylvania Medical Center. (1999, July 20). New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/1999/07/990720083803.htm
University Of Pennsylvania Medical Center. "New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments." ScienceDaily. www.sciencedaily.com/releases/1999/07/990720083803.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins