Featured Research

from universities, journals, and other organizations

New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments

Date:
July 20, 1999
Source:
University Of Pennsylvania Medical Center
Summary:
Researchers at the University of Pennsylvania Medical Center have devised a safer, more effective strategy for bone marrow transplantation that does not require the use of drugs that globally suppress the immune system.

Researchers at the University of Pennsylvania Medical Center have devised a safer, more effective strategy for bone marrow transplantation that does not require the use of drugs that globally suppress the immune system. A report on the new technique, demonstrated in mice, appears in the July 16 issue of Science.

Related Articles


Transplantation of bone marrow, which gives rise to all types of blood cells in the body, including immune system cells, is useful in treating cancers of the blood and inherited blood disorders. Because it is the source of the cells that constitute the immune system, however, bone marrow transplantation sometimes leads to a potentially quite serious condition called graft-versus-host disease, or GVHD, in which T cells produced by the donor marrow attack the host, i.e., the patient receiving the transplant.

For this reason, powerful drugs that suppress the immune system, primarily by paralyzing T cells, are given to bone marrow transplant recipients to control GVHD. Immune suppression carries its own costs, however, leaving the patient vulnerable to infections and other problems.

The new approach used by the Penn scientists involves inactivating a subset of immune-system cells in the transplant recipient called antigen-presenting cells, or APCs. Although the patient's existing bone marrow is destroyed prior to transplantation - largely to preclude GVHD - APCs originating from that marrow continue to circulate in the patient's blood. Those APCs serve as the trigger for T cells produced by the newly received bone marrow to attack cells in the patient. When these APCs were disabled, however, GVHD was entirely prevented.

"Most techniques for immunosuppression are based upon paralyzing T cells," says Stephen G. Emerson, MD, chief of the division of hematology-oncology, professor of medicine, and senior author on the report. "They're global, and they have serious limitations. Targeting antigen-presenting cells, however, provides a different cell type to focus on for immunosuppression, with the idea of inhibiting host antigen presentation and stopping the process of immune stimulation right at the beginning."

The lead author on the report is Warren D. Shlomchik. The other Penn-based authors are Matthew S. Couzens and Cheng Bi Tang. The coauthors affiliated with Yale University are Jennifer McNiff, Marie E. Robert, Jinli Liu, and Mark J. Shlomchik.


Story Source:

The above story is based on materials provided by University Of Pennsylvania Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Pennsylvania Medical Center. "New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments." ScienceDaily. ScienceDaily, 20 July 1999. <www.sciencedaily.com/releases/1999/07/990720083803.htm>.
University Of Pennsylvania Medical Center. (1999, July 20). New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/1999/07/990720083803.htm
University Of Pennsylvania Medical Center. "New Bone Marrow Transplantation Technique Promises Safer, More Effective Cancer Treatments." ScienceDaily. www.sciencedaily.com/releases/1999/07/990720083803.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins