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Lab Experiments Reveal Potential Therapeutic Target For Degenerative Brain Diseases

Date:
August 3, 1999
Source:
National Institute Of Allergy And Infectious Diseases
Summary:
Laboratory experiments on prion diseases - degenerative brain illnesses such as Kuru and Crutzfeldt-Jakob disease in humans, scrapie in sheep, and the so-called "mad cow disease" - have yielded a surprising clue to what may be a way to prevent these diseases.

Laboratory experiments on prion diseases - degenerative brain illnesses such as Kuru and Crutzfeldt-Jakob disease in humans, scrapie in sheep, and the so-called "mad cow disease" - have yielded a surprising clue to what may be a way to prevent these diseases. In the August issue of the Journal of Virology, scientists from the National Institute of Allergy and Infectious Diseases (NIAID) and their colleagues in France and the United Kingdom report that a small piece of the prion protein (PrP) prevents the larger molecule from folding incorrectly. Since abnormal folding is associated with prion disease, blocking the ability of the prion protein to assume an abnormal shape could be key to blocking progression to disease.


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The above story is based on materials provided by National Institute Of Allergy And Infectious Diseases. Note: Materials may be edited for content and length.


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National Institute Of Allergy And Infectious Diseases. "Lab Experiments Reveal Potential Therapeutic Target For Degenerative Brain Diseases." ScienceDaily. ScienceDaily, 3 August 1999. <www.sciencedaily.com/releases/1999/08/990802163210.htm>.
National Institute Of Allergy And Infectious Diseases. (1999, August 3). Lab Experiments Reveal Potential Therapeutic Target For Degenerative Brain Diseases. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/1999/08/990802163210.htm
National Institute Of Allergy And Infectious Diseases. "Lab Experiments Reveal Potential Therapeutic Target For Degenerative Brain Diseases." ScienceDaily. www.sciencedaily.com/releases/1999/08/990802163210.htm (accessed April 20, 2014).

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