Featured Research

from universities, journals, and other organizations

Genetic Resistance To Chemically-Induced Diabetes In Mice Linked To Elevated Antioxidant Levels

Date:
August 11, 1999
Source:
Jackson Laboratory
Summary:
Research at The Jackson Laboratory comparing mice bred for resistance or susceptibility to chemically-induced insulin-dependent (Type 1) diabetes suggests that the major difference is in the genetic control of antioxidant enzymes. These enzymes help protect against pancreatic beta-cell destruction caused by free radical-mediated stress in both mice and humans.

Research at The Jackson Laboratory comparing mice bred for resistance or susceptibility to chemically-induced insulin-dependent (Type 1) diabetes suggests that the major difference is in the genetic control of antioxidant enzymes. These enzymes help protect against pancreatic beta-cell destruction caused by free radical-mediated stress in both mice and humans.

Related Articles


The results add a new dimension in understanding why some humans with "high-risk" genes for developing Type 1 diabetes remain free of this disease. Identification of the gene or genes conferring such remarkable resistance could lead to therapies to boost natural defenses against diabetes and improve survival of pancreatic islet transplants.

"These studies in model systems suggest that the extent to which an individual can detoxify free radicals as they form in pancreatic beta cells may be an important component of genetically inherited susceptibility or resistance to diabetes," said Clayton E. Mathews, a Postdoctoral Associate at The Jackson Laboratory.

The research is published in the August 1999 issue of Free Radical Biology & Medicine by Dr. Mathews and Senior Staff Scientist Dr. Edward H. Leiter. Their paper is entitled, "Constitutive Differences in Antioxidant Defense Status Distinguish Alloxan-Resistant and Alloxan-Susceptible Mice."

The scientists focused on ALR (alloxan-resistant) and ALS (alloxan-susceptible) inbred mice, developed by F. Sekiguchi and colleagues in Japan as a model animal system for diabetes induced by an environmental toxin known as alloxan. This potent chemical generates free radicals, or reactive oxygen species, which contribute to beta cell destruction in Type 1 diabetes and damage to eyes, kidney, heart, and nerves associated with both Type 1 and Type 2 (non-insulin dependent) diabetes.

Past research has shown that the beta-cell death induced by alloxan can be inhibited by the use of antioxidants. Dietary supplementation of vitamin E, selenium, or zinc is protective against experimentally induced diabetes, while their depletion enhances the development of diabetes.

In their experiment, Drs. Mathews and Leiter found upregulation of a diverse group of antioxidant enzymes in the resistant mice as compared to the susceptible mice, including elevated superoxide dismutase, glutathione reductase, and glutathione peroxidase in the pancreas and other tissues systemwide.

A controlled cross between the ALS and ALR strains resulted in all F1 offspring of both sexes exhibiting resistance to alloxan-induced diabetes, suggesting that the unusually high free radical defense trait in ALR may provide protection when transferred into the susceptible strain. A subsequent F1 backcross to ALS strongly supports the hypothesis that the trait is attributable to a single gene.

Drs. Mathews and Leiter have proposed that the genetic resistance of ALR mice to diabetogenic stress may be attributed to differences in expression of a transcription factor that activates a battery of stress-response genes. Transcription factors are molecules that turn on or off the process of protein synthesis in which genes are copied for activation in the cell.

The research was supported by individual grants from the American Diabetes Association, the Juvenile Diabetes Federation International, and the National Institutes of Health, as well as an institutional grant from the National Cancer Institute.


Story Source:

The above story is based on materials provided by Jackson Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Jackson Laboratory. "Genetic Resistance To Chemically-Induced Diabetes In Mice Linked To Elevated Antioxidant Levels." ScienceDaily. ScienceDaily, 11 August 1999. <www.sciencedaily.com/releases/1999/08/990811080323.htm>.
Jackson Laboratory. (1999, August 11). Genetic Resistance To Chemically-Induced Diabetes In Mice Linked To Elevated Antioxidant Levels. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/1999/08/990811080323.htm
Jackson Laboratory. "Genetic Resistance To Chemically-Induced Diabetes In Mice Linked To Elevated Antioxidant Levels." ScienceDaily. www.sciencedaily.com/releases/1999/08/990811080323.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Pot-Infused Edibles Raise Concerns in Colorado

Pot-Infused Edibles Raise Concerns in Colorado

AFP (Oct. 30, 2014) Colorado may have legalized marijuana for recreational use, but the debate around the decision still continues, with a recent - failed - attempt to ban cannabis-infused edibles. Duration: 01:53 Video provided by AFP
Powered by NewsLook.com
British Navy Ship Arrives in Sierra Leone With Ebola Aid

British Navy Ship Arrives in Sierra Leone With Ebola Aid

AFP (Oct. 30, 2014) The British ship RFA ARGUS arrived in Sierra Leone to deliver supplies and equipment to help the fight against Ebola. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins