Featured Research

from universities, journals, and other organizations

Iowa Research Team Discovers New Genes Involved In The Spread Of Breast Cancer

Date:
August 24, 1999
Source:
University Of Iowa
Summary:
Findings from a University of Iowa Health Care study may provide important new clues in understanding how breast cancer spreads. According to findings published in the August issue of Breast Cancer Research and Treatment, a team of UI investigators has identified new genes involved in the invasive and metastatic spread of breast cancer.

IOWA CITY, Iowa -- Findings from a University of Iowa Health Care study may provide important new clues in understanding how breast cancer spreads.

Related Articles


According to findings published in the August issue of Breast Cancer Research and Treatment, a team of UI investigators has identified new genes involved in the invasive and metastatic spread of breast cancer.

"After three years of intensive molecular screening, we are ecstatic about the prospects of developing our work for future clinical applications," said Mary J.C. Hendrix, Ph.D., UI professor and head of anatomy and cell biology, and associate director of basic research and deputy director of the UI Cancer Center.

Although researchers believe breast cancer spreads through a complex, multi-step process involving alterations or loss of specific genes, little is known about the function, molecular regulation and interaction of these genetic alterations. The first step to understanding how these "misregulated" genes lead to the spread of breast cancer is to identify them and study their function.

Through a molecular approach called differential display analysis, Hendrix's investigative team identified the genes lysyl oxidase and a zinc finger transcription factor in highly aggressive breast cancer cells that spread. In addition, the researchers showed that a thiolspecific antioxidant and heterochromatin-associated protein 1-Hs-alpha were dramatically decreased in these same cells, thus suggesting their potential as tumor suppressor genes that are lost in breast cancer.

"Although the precise roles of these genes remains obscure, identifying the genes is an important first step in understanding the complex process of tumor cell invasion and metastasis," Hendrix said. "Armed with this information, our lab is now investigating the regulation and biological significance of these genes, which may help us to better understand the molecular and biochemical basis of tumor cell progression and possibly contribute to identifying new therapeutic targets for disease intervention."

Members of Hendrix's UI research team who contributed to this study include: Dawn A. Kirschmann Ph.D., assistant research scientist; Elisabeth A. Seftor, Ph.D., senior research specialist; Daniel R.C. Nieva, a first-year medical student; and Elpidio A. Mariano, a second-year medical student. The work was funded by a grant from the National Cancer Institute.


Story Source:

The above story is based on materials provided by University Of Iowa. Note: Materials may be edited for content and length.


Cite This Page:

University Of Iowa. "Iowa Research Team Discovers New Genes Involved In The Spread Of Breast Cancer." ScienceDaily. ScienceDaily, 24 August 1999. <www.sciencedaily.com/releases/1999/08/990824074717.htm>.
University Of Iowa. (1999, August 24). Iowa Research Team Discovers New Genes Involved In The Spread Of Breast Cancer. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/1999/08/990824074717.htm
University Of Iowa. "Iowa Research Team Discovers New Genes Involved In The Spread Of Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/1999/08/990824074717.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins