Featured Research

from universities, journals, and other organizations

Hormone Linked To Body Weight May Help Regulate Blood Pressure

Date:
September 17, 1999
Source:
American Heart Association
Summary:
Leptin, a hormone believed to help regulate body weight, may also be involved in the regulation of blood pressure, according to research presented at the American Heart Association's meeting on high blood pressure.

ORLANDO, Fla., Sept. 15 -- Leptin, a hormone believed to help regulate body weight, may also be involved in the regulation of blood pressure, according to research presented today at the American Heart Association's meeting on high blood pressure.

Related Articles


"It is possible that leptin is one of the regulators of blood pressure," says Hideki Takizawa, M.D., Ph.D., an instructor in the second department of internal medicine at the Sapporo Medical University in Sapporo, Japan.

In an earlier study, Takizawa's group found that blood levels of leptin were higher in normal weight people with high blood pressure than in individuals of similar size who had normal blood pressure. To further evaluate the relationship between leptin and blood pressure, the researchers studied 133 men and 263 women under age 65 who did not have diabetes and also had not taken medication for high blood pressure.

Leptin is a hormone manufactured in fat cells of the body. It affects food intake and energy expenditures by interacting with a receptor in the brain. Previous studies involving mice found that those who are missing the gene that regulates leptin production become fat. When they are given leptin, they eat less and lose weight.

But the situation is less clear-cut in humans. Obese people tend to have high leptin levels. Researchers believe these individuals may have a leptin resistance that blocks their ability to recognize or respond to the hormone.

When researchers adjusted for age, body mass index and insulin, they found that men with higher leptin levels also had higher diastolic blood pressure -- the pressure when the heart is resting between beats. "The data clearly indicate that high leptin levels are related to high blood pressure," Takizawa says.

He adds that although other studies have found that weight loss leads to a reduction in high blood pressure and leptin levels, further research is needed to determine if reduced leptin levels due to weight loss can reduce a person's risk of high blood pressure.

"Several factors are believed to affect leptin levels," Takizawa says. "One is the amount of fat volume (quantity) a person has because leptin is produced in fat cells. A second factor is whether the fat is deposited near the surface of the skin or deeper within the body. A third consideration is insulin, which stimulates leptin production." Insulin is a hormone that helps the body use glucose, a main food source.

Because so many things could affect leptin levels, the researchers used a method called regression analysis, in which they adjusted for some variables in order to determine the relative importance of others.

High blood pressure greatly increases the risk of heart attack, stroke and kidney failure. An estimated one in four adult Americans has high blood pressure. Although the condition often has no symptoms, it is easy to diagnose and usually controllable.

Co-authors include: Nobuyuki Ura, M.D., Ph.D.; Shigeyuki Saitoh, M.D., Ph.D.; Ling Wang, M.D.; Katsuhiro Higashiura, M.D., Ph.D.; Satoru Takagi, M.D., Ph.D.; Mikio Takada, M.D.; Nobuhiko Togashi, M.D.; Masahiro Nakano, M.D.; and Kazuaki Shimamoto, M.D., Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Hormone Linked To Body Weight May Help Regulate Blood Pressure." ScienceDaily. ScienceDaily, 17 September 1999. <www.sciencedaily.com/releases/1999/09/990917073637.htm>.
American Heart Association. (1999, September 17). Hormone Linked To Body Weight May Help Regulate Blood Pressure. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/1999/09/990917073637.htm
American Heart Association. "Hormone Linked To Body Weight May Help Regulate Blood Pressure." ScienceDaily. www.sciencedaily.com/releases/1999/09/990917073637.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins