Featured Research

from universities, journals, and other organizations

Drug Offers New Hope For Victims Of Cardiac Arrest

Date:
September 20, 1999
Source:
University Of Washington
Summary:
A clinical trial performed by University of Washington researchers, reported in the Sept. 16 issue of the New England Journal of Medicine, shows that an intravenous anti-arrhythmia medication, amiodarone, can save the lives of many patients who do not respond to defibrillation.

The threat of imminent death awaits the 250,000 persons who suffer a cardiac arrest outside the hospital each year, especially those for whom defibrillation fails to shock the heart back to normal beating.

A clinical trial performed by University of Washington researchers, reported in the Sept. 16 issue of the New England Journal of Medicine, shows that an intravenous anti-arrhythmia medication, amiodarone, can save the lives of many patients who do not respond to defibrillation.

Dr. Peter Kudenchuk, associate professor of medicine and director of arrhythmia services at University of Washington Medical Center in Seattle, and colleagues performed the study, called ARREST (Amiodarone in the Out-of-Hospital Resuscitation of Refractory Sustained Ventricular Tacharrhythmias). The study was performed in conjunction with Medic One, Seattle/King County's highly regarded emergency response service based at Harborview Medical Center.

They found that resuscitation to a stable heart rhythm was improved by nearly 30 percent in people treated with intravenous amiodarone by emergency medical personnel at the scene of their collapse, compared to those who received other standard treatments for cardiac arrest.

This benefit was seen even when amiodarone was given late in the course of resuscitation, and was especially evident in women compared to men.

Kudenchuk noted that the clinical trial is the first of its kind to compare the effectiveness of an anti-arrhythmia medication with all standard treatments in victims of out-of-hospital cardiac arrest.

The drug was administered to 504 people in Seattle and surrounding King County, Wash., who suffered cardiac arrest due to a dangerous heart rhythm (ventricular fibrillation) and were treated at the scene by Medic One. Patients ranged in age from 20 to 94 years. The majority were men and the majority went into cardiac arrest at home.

"For every 10 persons treated with amiodarone for shock-resistant cardiac arrest, one additional person was resuscitated and admitted alive to the hospital," said Kudenchuk.

He noted that the main treatment endpoint for the ARREST trial was being successfully resuscitated and admitted to the hospital. The trial was not designed to evaluate the effect of amiodarone treatment on outcome after hospitalization. Although a small improvement in survival to hospital discharge with full recovery of brain function was observed in persons treated with amiodarone, the investigators did not feel that this difference was conclusive.

"Stopping the cardiac arrest and successfully getting patients to the hospital is a big step, but it's only the first hurdle," said Kudenchuk. "The next step is to determine whether drugs like amiodarone can improve long-term survival after cardiac arrest. "

Amiodarone is marketed as Cordarone IV by Wyeth-Ayerst Laboratories. The Medic One Foundation provided approximately two-thirds of the funding for the study and Wyeth-Ayerst, approximately one-third.


Story Source:

The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


Cite This Page:

University Of Washington. "Drug Offers New Hope For Victims Of Cardiac Arrest." ScienceDaily. ScienceDaily, 20 September 1999. <www.sciencedaily.com/releases/1999/09/990920072033.htm>.
University Of Washington. (1999, September 20). Drug Offers New Hope For Victims Of Cardiac Arrest. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/1999/09/990920072033.htm
University Of Washington. "Drug Offers New Hope For Victims Of Cardiac Arrest." ScienceDaily. www.sciencedaily.com/releases/1999/09/990920072033.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins