Featured Research

from universities, journals, and other organizations

Gamma/Delta T Cells Essential To Regulating Airway Hyperresponsiveness In Asthma, Other Lung Diseases, According To National Jewish Researchers

Date:
September 28, 1999
Source:
National Jewish Medical And Research Center
Summary:
Airway hyperresponsiveness, a feature of asthma, chronic obstructive pulmonary disease and environmental lung diseases, may be linked to a lack of gamma/delta T cells in the lungs National Jewish researchers have found.

DENVER - Airway hyperresponsiveness, a feature commonly found in diseases such as asthma, chronic obstructive pulmonary disease and environmental lung diseases, may be linked to a lack of gamma/delta T cells in the lungs National Jewish Medical and Research Center scientists write in today’s Nature Medicine.

Related Articles


The research sheds light on a previously unknown immune system mechanism that depends on gamma/delta T cells, found in small numbers in the lungs, to stop airway constriction independently of other T cells.

“Gamma/delta T cells in the lungs are a small population, but have a big impact,” said Michael Lahn, M.D., a National Jewish Fellow and an author of the study. Dr. Lahn and Arihiko Kanehiro, M.D., both National Jewish Fellows, are principal authors of the study.

The research found that gamma/delta T cells ensure that airways are relaxed each time they are exposed to stimuli, such as a protein used to create a model of asthma in mice. Airways of mice without gamma/delta T cells in their lungs constricted significantly when exposed to airway stimuli, according to the research. In comparison, mice deficient in another type of T cell did not have airway constriction, leading the scientists to judge that gamma/delta T cells have a suppressive effect on airway hyperresponsiveness.

“This was a very surprising finding,” Dr. Lahn said. “Even more surprising was that everything implicated in causing airway hyperresponsiveness in the past was not detected, such as evidence of inflammation.”

Found in already limited numbers in the lungs of people without asthma, gamma/delta T cells are observed in even smaller numbers in the lungs of people with the lung disease. Whether reduced gamma/delta T cells in these patients increase the likelihood for wheezing needs to be addressed with further research, Dr. Lahn said.

“Gamma/delta T cells are essential in day-to-day regulation of the airways,” he said. “And they control, in a very potent way, stressful events anytime the lungs or the airways get exposed to airway stimuli.”

In the future, as scientists learn more about how gamma/delta T cells work and interact with other T cells, it’s possible that people with asthma and other lung diseases could use medication to boost their level of gamma/delta T cells, which would lower airway hyperresponsiveness.

The labs of Willi Born, Ph.D., Erwin Gelfand, M.D. and Rebecca O’Brien, Ph.D., collaborated in this research. Dr. Lahn is a Fellow in Dr. Born’s lab; Dr. Kanehiro is a Fellow in Dr. Gelfand’s lab.

The National Institutes of Health and the U.S. Environmental Protection Agency funded this study.

The Number 1 Respiratory Hospital in the U.S. for Two Consecutive Years, U.S. News & World Report, 1998-2000.

Web site: http://www.nationaljewish.org/pa


Story Source:

The above story is based on materials provided by National Jewish Medical And Research Center. Note: Materials may be edited for content and length.


Cite This Page:

National Jewish Medical And Research Center. "Gamma/Delta T Cells Essential To Regulating Airway Hyperresponsiveness In Asthma, Other Lung Diseases, According To National Jewish Researchers." ScienceDaily. ScienceDaily, 28 September 1999. <www.sciencedaily.com/releases/1999/09/990924112111.htm>.
National Jewish Medical And Research Center. (1999, September 28). Gamma/Delta T Cells Essential To Regulating Airway Hyperresponsiveness In Asthma, Other Lung Diseases, According To National Jewish Researchers. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/1999/09/990924112111.htm
National Jewish Medical And Research Center. "Gamma/Delta T Cells Essential To Regulating Airway Hyperresponsiveness In Asthma, Other Lung Diseases, According To National Jewish Researchers." ScienceDaily. www.sciencedaily.com/releases/1999/09/990924112111.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins