Featured Research

from universities, journals, and other organizations

Researchers Complete Sequence And Gene Map Of Human Major Histocompatibility Complex

Date:
October 28, 1999
Source:
Fred Hutchinson Cancer Research Center
Summary:
Researchers are reporting the genomic sequence of the major histocompatibility complex (MHC), a region on chromosome 6 essential to the immune system. The MHC controls many activities of the immune cells, including the transplantation rejection process and the killing of virus-infected cells by specific killer T lymphocytes. This region harbors several disease associations and the variability in this region between donor and recipient is a critical factor in marrow transplant matching.

A paper authored by members of the MHC sequencing consortium is scheduled for the Oct. 28 issue of the journal Nature.

Related Articles


The paper describes the genomic sequence of the major histocompatibility complex (MHC), a region on chromosome 6 essential to the immune system. The MHC controls many activities of the immune cells, including the transplantation rejection process and the killing of virus-infected cells by specific killer T lymphocytes. This region harbors several disease associations and the variability in this region between donor and recipient is a critical factor in marrow transplant matching.

This is the first complete sequence and gene map of the MHC. This information will enable researchers to identify the positions of genes on this important segment of the human genome, helping to understand the origin of many common diseases.

In the immediate future, the sequence provides a vital tool towards improved diagnosis of disease and choice of marrow transplant recipient, by providing information that will allow us to much more accurately relate genetic variability among people to their potential for developing a large number of disease susceptibilities. This should allow for more immediate and precise diagnosis.

"This new knowledge should rapidly lead to straightforward and accurate diagnostic tests based on actual gene sequences. This should make it easier for doctors to influence the progression of some diseases by giving lifestyle advice," said Daniel Geraghty, co-author of the paper.

In the longer term, understanding the structure of disease susceptibility genes may lead to more effective treatments of existing disease. In addition to being critical in the marrow transplant process, the MHC has a large number and variety of disease associations, and thus the scope of this advance would have the potential for a broad impact on human health.

The MHC Consortium includes (alphabetical order): Drs. Stephen Beck of The Sanger Centre, Daniel E. Geraghty, Fred Hutchinson Cancer Research Center, H. Inoko with the Department of Life Sciences at Tokai University School of Medicine and Lee Rowen and Leroy Hood at the University of Washington.


Story Source:

The above story is based on materials provided by Fred Hutchinson Cancer Research Center. Note: Materials may be edited for content and length.


Cite This Page:

Fred Hutchinson Cancer Research Center. "Researchers Complete Sequence And Gene Map Of Human Major Histocompatibility Complex." ScienceDaily. ScienceDaily, 28 October 1999. <www.sciencedaily.com/releases/1999/10/991028072039.htm>.
Fred Hutchinson Cancer Research Center. (1999, October 28). Researchers Complete Sequence And Gene Map Of Human Major Histocompatibility Complex. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/1999/10/991028072039.htm
Fred Hutchinson Cancer Research Center. "Researchers Complete Sequence And Gene Map Of Human Major Histocompatibility Complex." ScienceDaily. www.sciencedaily.com/releases/1999/10/991028072039.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins