Featured Research

from universities, journals, and other organizations

UT Southwestern Researchers Develop Tumor Index To Diagnose Ovarian Cancer

Date:
December 29, 1999
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
UT Southwestern Medical Center at Dallas researchers have developed a new ovarian tumor index that will help physicians accurately diagnose ovarian tumors as either cancerous or benign and hopefully save thousands of women from unnecessary surgeries.

DALLAS - December 27, 1999 - UT Southwestern Medical Center at Dallas researchers have developed a new ovarian tumor index that will help physicians accurately diagnose ovarian tumors as either cancerous or benign and hopefully save thousands of women from unnecessary surgeries.

The majority of women who have ovarian tumors, confirmed through ultrasound, discover after major surgery that their tumors were benign, but physicians have such a difficult time diagnosing this deadly cancer that many recommend aggressive treatment just in case.

"The early detection of ovarian cancer is a formidable challenge and an elusive task," said Dr. Diane Twickler, associate professor of radiology and obstetrics and gynecology and an author of the report in the December issue of Cancer. "The index is a valuable way of interpreting a complex set of ultrasound findings in a reasonable fashion that will help the referring physician plan further testing, surgery or other clinical management."

Fellow author Dr. David Scott Miller, professor of obstetrics and gynecology, agreed. "The words 'ovarian cancer' are probably the most terrifying to women. And that's because it's so hard to diagnose and, thus, so deadly," Miller said.

"It may be possible that if the index indicates the mass is benign, she may be able to have a far less traumatic procedure, such as a laparoscopy," Miller said. "The information from the index may also help the physician decide whether he or she should perform the surgery or refer to a cancer specialist."

The index can also indicate which patients would benefit from serum monitoring - a series of blood tests that reveal proliferating cancer cells, Miller said.

The index was developed by evaluating characteristics of malignant and nonmalignant masses through real-time ultrasound, measurements of flow, structural measurements and checks for vessel location with methods such as color mapping. The most definitive characteristic proved to be the patient's age. The study showed a logical correlation between the patient's age and the chance of malignancy.

Of the 304 women in the study, 244 had follow-up care at UT Southwestern, which allowed their outcomes to be correlated with their prospective ultrasounds. Of those patients, 214 were diagnosed with noncancerous masses, while 30 had neoplasms that proved cancerous. Eighty-five of the noncancerous masses were benign neoplasm-type tumors. Peri-menopausal, menopausal and post-menopausal women were all included.

As the researchers suspected, patient age and the appearance, size and blood flow as revealed by ultrasound were significantly different in cancerous and noncancerous lesions. Larger, vascular tumors with abnormal appearances were more likely to represent malignant disease. Younger patients were more likely than older patients to have benign tumors.

Researchers assigned numbers to reflect the various ultrasound results. Patient-age numbers were also added to the formula. Twickler said the index's relative probability assignments are "a desirable alternative to and more realistic than absolute cut-off values between malignant and nonmalignant neoplasms."

Besides Twickler and Miller, other researchers in the study included Drs. Thalia B. Forte, assistant professor of radiology; Rigoberto Santo-Ramos, professor of obstetrics and gynecology; and Donald McIntire, assistant professor of obstetrics and gynecology.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Develop Tumor Index To Diagnose Ovarian Cancer." ScienceDaily. ScienceDaily, 29 December 1999. <www.sciencedaily.com/releases/1999/12/991229121816.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1999, December 29). UT Southwestern Researchers Develop Tumor Index To Diagnose Ovarian Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/1999/12/991229121816.htm
University Of Texas Southwestern Medical Center At Dallas. "UT Southwestern Researchers Develop Tumor Index To Diagnose Ovarian Cancer." ScienceDaily. www.sciencedaily.com/releases/1999/12/991229121816.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins