Featured Research

from universities, journals, and other organizations

Common Enzyme Deficiency May Jeopardize Pregnancies

Date:
January 4, 2000
Source:
University Of Toronto
Summary:
A hereditary enzyme deficiency increases the incidence of fetal death and birth defects in mice, a discovery that may have implications for the over 400 million people around the world who have the condition, says a University of Toronto study published in the January issue of The Federation of American Societies for Experimental Biology Journal.

A hereditary enzyme deficiency increases the incidence of fetal death and birth defects in mice, a discovery that may have implications for the over 400 million people around the world who have the condition, says a study published in the January issue of The Federation of American Societies for Experimental Biology Journal.

The study found the first evidence that the enzyme, glucose-6-phosphate dehydrogenase (G6PD), is critical to the healthy development of embryos. Without G6PD, embryonic cells are susceptible to damage caused by reactive oxygen species -- or free radicals -- that occur as a result of normal development or the introduction of certain drugs and environmental chemicals during pregnancy. In people without the deficiency, G6PD is an antioxidant enzyme that protects cells from the harmful effects of these normal and drug-enhanced oxidative stresses.

The researchers compared the pregnancies of mutant mice with various degrees of G6PD deficiency to normal mice and found higher rates of prenatal and postnatal death in the deficient group. Another group of mutant mice was treated with a drug known to create oxidative stress called phenytoin, the most common anti-epileptic drug in North America. Phenytoin's oxidant effect is comparable to that of many other drugs and chemicals in the environment.

"Even without any treatment at all, mouse embryos that were deficient in the enzyme were more likely to suffer just from the oxidative stress that happens naturally during development," says co-author Peter Wells of the University of Toronto's Faculty of Pharmacy. "Then when we exposed them to a drug that produces reactive oxygen species, the embryonic death rates and incidence of birth defects in the surviving fetuses went through the roof, although the mothers remained healthy. The next question is, will we find the same results in humans?" Until now, Wells says, the only health risk associated with the deficiency was the premature destruction of red blood cells in adults exposed to oxidant drugs like antimalerial agents. There have been no investigations of the impact of the hereditary condition on developing embryos.

"This is an enzyme that's been around forever and people have always thought it was of only limited toxicological interest," says Wells. "Presumably these new findings will now stimulate people to start looking carefully at mothers with the hereditary enzyme deficiency to see whether, for example, it takes longer for them to get pregnant -- because they may be unknowingly conceiving and then losing their babies very early on -- or they have more miscarriages or have more children with birth defects."

Screening for G6PD deficiency is a simple process, Wells says, and if studies show it causes similar problems in human pregnancy then potential antioxidant therapies could be evaluated for their safety in pregnant women.

Deficiencies in G6PD are the most common enzyme deficiency in humans, with people from Mediterranean, African and Asian countries affected in the highest numbers. Wells' co-authors were Christopher Nicol of the department of pharmacology, Lap-Chee Tsui of the Hospital for Sick Children's department of genetics and U of T's department of medical genetics and microbiology and Julian Zielenski of HSC's department of genetics.

CONTACT:
Megan Easton
U of T Public Affairs
(416) 978-5948
megan.easton@utoronto.ca
http://www.newsandevents.ca


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Common Enzyme Deficiency May Jeopardize Pregnancies." ScienceDaily. ScienceDaily, 4 January 2000. <www.sciencedaily.com/releases/2000/01/000103150318.htm>.
University Of Toronto. (2000, January 4). Common Enzyme Deficiency May Jeopardize Pregnancies. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2000/01/000103150318.htm
University Of Toronto. "Common Enzyme Deficiency May Jeopardize Pregnancies." ScienceDaily. www.sciencedaily.com/releases/2000/01/000103150318.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins