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New Link Uncovered In Nerve Cell Mechanism Thought To Power Learning And Memory

Date:
March 28, 2000
Source:
Cold Spring Harbor Laboratory
Summary:
Researchers at Cold Spring Harbor Laboratory have uncovered a significant new link in the molecular chain of events thought to underlie learning and memory. By using a novel electrophysiological method for measuring synaptic activity, Roberto Malinow and his colleagues have demonstrated that strengthening of nerve cell connections in the brain -- believed to occur during learning and memory consolidation -- can be largely explained by the movement of proteins called AMPA receptors into synapses.

Cold Spring Harbor, NY -- Researchers at Cold Spring Harbor Laboratory have uncovered a significant new link in the molecular chain of events thought to underlie learning and memory. By using a novel electrophysiological method for measuring synaptic activity, Roberto Malinow and his colleagues have demonstrated that strengthening of nerve cell connections in the brain -- believed to occur during learning and memory consolidation -- can be largely explained by the movement of proteins called AMPA receptors into synapses. The scientists describe the role of two other proteins, one (a protein kinase) known previously to be critical to AMPA receptor-mediated synaptic strengthening, and another (the new link) whose existence is strongly implicated by the recent findings. The study is reported in the March 23 issue of Science.


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The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "New Link Uncovered In Nerve Cell Mechanism Thought To Power Learning And Memory." ScienceDaily. ScienceDaily, 28 March 2000. <www.sciencedaily.com/releases/2000/03/000328090224.htm>.
Cold Spring Harbor Laboratory. (2000, March 28). New Link Uncovered In Nerve Cell Mechanism Thought To Power Learning And Memory. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2000/03/000328090224.htm
Cold Spring Harbor Laboratory. "New Link Uncovered In Nerve Cell Mechanism Thought To Power Learning And Memory." ScienceDaily. www.sciencedaily.com/releases/2000/03/000328090224.htm (accessed April 19, 2014).

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