Featured Research

from universities, journals, and other organizations

New Class Of Drugs For Erectile Dysfunction Unveiled

Date:
April 11, 2000
Source:
American Chemical Society
Summary:
Scientists at Bristol-Myers Squibb have identified a promising new class of drugs that may yield strong candidates for the treatment of erectile dysfunction (also known as impotence) that may be more potent and have fewer side effects than the popular Viagra®, they say. The findings will appear in the April 6 print issue of the peer-reviewed Journal of Medicinal Chemistry, published by the American Chemical Society.

May Be More Potent, Have Fewer Side Effects Than Viagra®

Related Articles


Scientists at Bristol-Myers Squibb have identified a promising new class of drugs that may yield strong candidates for the treatment of erectile dysfunction (also known as impotence) that may be more potent and have fewer side effects than the popular Viagra®, they say. The findings will appear in the April 6 print issue of the peer-reviewed Journal of Medicinal Chemistry, published by the American Chemical Society, the world’s largest scientific society.

Although none of these compounds has been tested in humans, the researchers believe that the current study points toward promising new treatments for erectile dysfunction.

The first reliable oral medication for the treatment of erectile dysfunction, Viagra® (known generically as sildenafil) has surged in popularity since its introduction two years ago. It helps maintain an erection by blocking the action of an enzyme called phosphodiesterase type 5 in penile tissue.

Phosphodiesterase has several different forms. Researchers believe that sildenafil lacks specificity for certain forms of the enzyme — notably, type 1 and type 6 — and that non-selective blockade of these enzymes may trigger some of the drug’s adverse side effects, especially facial flushing and visual disturbances.

In an effort to create a better drug, the researchers identified a novel class of phosphodiesterase inhibitors that act on the same target as sildenafil. Using an animal tissue model for erectile dysfunction, the researchers tested these compounds in the laboratory and found that they were as potent as sildenafil in achieving relaxation of the smooth muscle tissues. This corresponds to improved erectile function in humans, they say.

When tested against isolated phosphodiesterase enzymes, this series of drug candidates was more potent than sildenafil against phosphodiesterase type 5 as well as more selective against other phosphodiesterase enzymes, the researchers say. “More potency” means that less of the drug can be given to patients while achieving the same therapeutic effect; “more specificity” means that fewer side effects are likely to occur.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "New Class Of Drugs For Erectile Dysfunction Unveiled." ScienceDaily. ScienceDaily, 11 April 2000. <www.sciencedaily.com/releases/2000/04/000410084314.htm>.
American Chemical Society. (2000, April 11). New Class Of Drugs For Erectile Dysfunction Unveiled. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2000/04/000410084314.htm
American Chemical Society. "New Class Of Drugs For Erectile Dysfunction Unveiled." ScienceDaily. www.sciencedaily.com/releases/2000/04/000410084314.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins