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Key DNA Enzyme Can Tolerate More Mutations Than Expected

Date:
May 10, 2000
Source:
University Of Washington
Summary:
A new study from University of Washington researchers shows that a DNA polymerase -- an enzyme -- commonly used for scientific study can tolerate many different mutations and remain functional. The total number of different active mutant forms discovered, 8,000, is apparently the largest library of any polymerase yet known -- and it might be the largest library of any enzyme known.

Many of us saw films in school and think of DNA replication -- the duplication of the cell -- as involving a gliding double-helix that breaks apart and smoothly forms new cells as symphonic music swells in the background. But the latest scientific studies show that cell replication is in fact much different, and far more chaotic. There can be a widespread substitution of different elements of the cell, with all sorts of effects. Those effects can be helpful, as in evolutionary change, or bad, as in cells that run amok and form cancer.


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The above story is based on materials provided by University Of Washington. Note: Materials may be edited for content and length.


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University Of Washington. "Key DNA Enzyme Can Tolerate More Mutations Than Expected." ScienceDaily. ScienceDaily, 10 May 2000. <www.sciencedaily.com/releases/2000/05/000509003555.htm>.
University Of Washington. (2000, May 10). Key DNA Enzyme Can Tolerate More Mutations Than Expected. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2000/05/000509003555.htm
University Of Washington. "Key DNA Enzyme Can Tolerate More Mutations Than Expected." ScienceDaily. www.sciencedaily.com/releases/2000/05/000509003555.htm (accessed April 18, 2014).

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