Featured Research

from universities, journals, and other organizations

Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

Date:
June 12, 2000
Source:
Penn State
Summary:
Using human cell lines in experiments with mice, a team of researchers at Penn State's College of Medicine have isolated and characterized a gene, designated Breast-cancer Metastasis Suppressor 1 (BRMS1), that plays a role in blocking tumor cells' ability to spread and colonize secondary sites.

Using human cell lines in experiments with mice, a team of researchers at Penn State's College of Medicine have isolated and characterized a gene, designated Breast-cancer Metastasis Suppressor 1 (BRMS1), that plays a role in blocking tumor cells' ability to spread and colonize secondary sites.

Danny R. Welch, Ph.D., associate professor of pathology and leader of the Penn State team, says, "The gene provides a target to develop therapies that keep cancer localized. Initially, it may also be helpful for making proper diagnosis."

Welch and co-authors published their findings in the current (June 1st) issue of the journal, Cancer Research, in a paper, Functional Evidence for a Novel Human Breast Carcinoma Metastasis Suppressor, BRMS1 encoded at Chromosome 11q13. The co-authors are Dr. M. Jabed Seraj, former postdoctoral fellow now at the Department of Urology, University of Virginia; Dr. Rajeev S. Samant, postdoctoral fellow and Dr. Michael F. Verderame, assistant professor of medicine.

Welch's research group had previously shown that the introduction of a normal human chromosome 11 reduced the ability of a human breast cancer cell line to spread or metastasize by 70 to 90 percent, suggesting the presence of one or more suppressor genes on that chromosome. Other laboratories have estimated that between half and two thirds of patients with late stage breast cancer lose copies of chromosome 11.

By comparing cells containing the added chromosome 11, in which metastasis was suppressed, with metastatic breast cancer cells, the group found that BRMS1 was more highly expressed (i.e.. the gene is turned "on") in the nonmetastatic cells. They then cloned BRMS-1, introduced it into metastatic cells and showed in experiments with mice that BRMS-1 suppressed the ability of the breast cancer cells to metastasize to lungs and lymph nodes without affecting their ability to form a tumor in the breast.

Welch says the majority of cells within a tumor cannot complete the multistep process of metastasis. For cells to successfully metastasize, they must interact with a variety of host cells and then respond in the appropriate manner. If a cell fails to complete any of the many steps involved, it is nonmetastatic.

"It takes only one gene to block metastasis, whereas it takes many coordinated steps for metastatic disease to occur," he says.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Cite This Page:

Penn State. "Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene." ScienceDaily. ScienceDaily, 12 June 2000. <www.sciencedaily.com/releases/2000/06/000612084928.htm>.
Penn State. (2000, June 12). Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2000/06/000612084928.htm
Penn State. "Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene." ScienceDaily. www.sciencedaily.com/releases/2000/06/000612084928.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins