Featured Research

from universities, journals, and other organizations

Researchers Take Steps To Growing Replacement Blood Vessels

Date:
September 26, 2000
Source:
Ohio State University
Summary:
Heart attacks may be less deadly in the future, thanks to micro- and nanotechnology research just begun at Ohio State University. Researchers here are investigating ways to re-grow tiny blood vessels to keep damaged heart tissue alive after a heart attack, by a process called therapeutic angiogenesis.

COLUMBUS, Ohio -- Heart attacks may be less deadly in the future, thanks to micro- and nanotechnology research just begun at Ohio State University.

Related Articles


Researchers here are investigating ways to re-grow tiny blood vessels to keep damaged heart tissue alive after a heart attack, by a process called therapeutic angiogenesis.

"Our bodies already contain cells that trigger the growth of new blood vessels. We want to use those same cells to create seeds for blood vessels in the laboratory and transplant them into the body," said Nicanor Moldovan, research scientist and assistant professor in Ohio State's Biomedical Engineering Center, and Heart and Lung Institute.

He relayed the researchers' initial results in a presentation September 25 in Columbus at the BioMEMS and Biomedical Nanotechnology World 2000 conference, co-sponsored by Ohio State.

Moldovan admits that his plan of growing capillaries in tissue culture and implanting them in the body is very complex,and relies on ideas about blood vessel formation that are just beginning to emerge.

"We've had to deal with a lot of speculation or supposition, but our approach appears to be a very promising one," he said. "Of course, this is just our dream, but we are working on it."

In these earliest results, Moldovan and his colleagues have demonstrated that these "seed" cells, called endothelial cells, will grow in grooves carved in the surface of a soft transparent gel in the laboratory.

The researchers' ultimate plan is to grow endothelial cells inside or on the surface of silicon molds resembling capillaries. If the cells could assume the shape of capillaries under those conditions, they could one day be transplanted -- either alone or with some kind of carrier -- into the heart to start the replacement of blood vessels that died during a heart attack.

Showing that the cells can grow two-dimensionally following the shape of grooves in the gel is a necessary first step, Moldovan said.

To demonstrate that the cells were indeed following the shape of the grooves, Moldovan and his colleagues first had to develop a method to let them accurately view the shape of the tiny grooves, which measure only a few micrometers across -- less than the width of a human hair. Normal viewing instruments would have torn the delicate surface of the gel, he said.

They developed a method Moldovan characterizes as fast and inexpensive. After they scrape the tiny grooves into the gel, they spray the gel with even tinier fluorescent beads, which spill along the surface and fill the grooves. A quick look through the microscope reveals the location of the grooves.

The researchers then literally wash the beads from the gel, leaving its delicate surface intact.

Moldovan envisions that one day capillaries could be carried into the heart tissue by micromachines called "angiochips." Once inside the heart, the implants could begin to undo the damage of a heart attack.

This relates to his other work in the Biomedical Engineering Center at Ohio State, Moldovan said. There the aim is to the stimulate capillary growth by angiogenic drugs released from implantable silicon capsules.

"We probably couldn't bring tissue back in its original form, but we could try to re-vascularize, to make a heart beat again. Or, at least, keep the heart tissue from dying by creating new capillaries that would provide blood and oxygen as soon as possible," he said.

When it comes time to create three-dimensional molds to shape the capillaries, the researchers will turn from gel to silicon, Moldovan said. Methods already exist to create complex 3D shapes in the metal, he said, and his previous research demonstrated that endothelial cells could grow on silicon.

"Once we have proof that we can grow cells in specific three-dimensional shapes on or inside silicon, then we hope to come back to the tissue," he said.


Story Source:

The above story is based on materials provided by Ohio State University. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University. "Researchers Take Steps To Growing Replacement Blood Vessels." ScienceDaily. ScienceDaily, 26 September 2000. <www.sciencedaily.com/releases/2000/09/000926071701.htm>.
Ohio State University. (2000, September 26). Researchers Take Steps To Growing Replacement Blood Vessels. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2000/09/000926071701.htm
Ohio State University. "Researchers Take Steps To Growing Replacement Blood Vessels." ScienceDaily. www.sciencedaily.com/releases/2000/09/000926071701.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins