Featured Research

from universities, journals, and other organizations

Drug Decreases Blood Vessel Stiffness In Older Primates

Date:
January 31, 2001
Source:
NIH/National Institute On Aging
Summary:
A novel drug that breaks down vascular collagen bonds in the body significantly decreased the stiffness of blood vessels in older non-human primates, according to a study conducted by National Institute on Aging (NIA) scientists and others. The finding suggests the medication could be a new treatment for high blood pressure, heart failure, and certain vascular complications of diabetes.

A novel drug that breaks down vascular collagen bonds in the body significantly decreased the stiffness of blood vessels in older non-human primates, according to a study conducted by National Institute on Aging (NIA) scientists and others.* The finding suggests the medication could be a new treatment for high blood pressure, heart failure, and certain vascular complications of diabetes. ALT-711 (Alteon, Ramsey, New Jersey), a thiazolium-based compound, snips bonds or crosslinks created in the arteries and other tissues when glucose attaches to collagen. Crosslinks are cable-like structures that inhibit the natural flexibility of collagen strands. They tend to proliferate with age. Crosslinks appear to toughen tissues and may cause some of the deterioration associated with aging and diabetes, such as elevated systolic blood pressure, hardened arteries, and impaired kidney function.

Related Articles


In the study, six rhesus monkeys received doses of ALT-711 every other day for three weeks. Six weeks after the last treatment, all of the vessel walls tested were more flexible, and the effect persisted for more than four months after final administration of the drug. Blood flow through the heart also increased and this improvement persisted for nearly 10 months after the treatments ended. No significant changes in body weight or routine chemical measurements were detected during the follow-up period. The finding was published in the January 30, 2001 issue of Proceedings of the National Academy of Sciences.

"Arterial stiffening is a major factor in many of the vascular diseases associated with advancing age," said Edward Lakatta, M.D., co-author of the study and chief of the NIA's Laboratory of Cardiovascular Sciences. "The significance of this drug is it alters the properties of the arterial wall and makes it easier for the heart to eject blood into the blood vessels. These results, coupled with prior studies in smaller animals, certainly suggest that ALT-711 may be a safe and efficacious approach to decreasing the impact of arterial stiffness on cardiovascular health. However, further research, including on-going studies in people, will be needed in order to confirm and extend these findings."

The research was a joint effort by the NIA and Alteon, Inc., as part of the Cooperative Research and Development Act. The National Institute on Aging, one of 25 Institutes that constitute the National Institutes of Health, leads Federal efforts to support and conduct basic, clinical, epidemiological, and social research on aging and the special needs of older people. For more information about the NIA, visit the website at http://www.nih.gov/nia.

###

* P.V. Vaitkevicius, M. Lane, H. Spurgeon, D.K. Ingram, G. S. Roth, J.J. Egan, S. Vasan, D.R. Wagle, P. Ulrich, M. Brines, J.P. Wuerth, A. Cerami, and E.G. Lakatta, "A Novel Cross-link Breaker Has Sustained Effects On Arterial and Ventricular Properties In Older Rhesus Monkeys, Proceedings of the National Academy of Sciences, 98:3, pp. 1171-1175, 2001


Story Source:

The above story is based on materials provided by NIH/National Institute On Aging. Note: Materials may be edited for content and length.


Cite This Page:

NIH/National Institute On Aging. "Drug Decreases Blood Vessel Stiffness In Older Primates." ScienceDaily. ScienceDaily, 31 January 2001. <www.sciencedaily.com/releases/2001/01/010130071831.htm>.
NIH/National Institute On Aging. (2001, January 31). Drug Decreases Blood Vessel Stiffness In Older Primates. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2001/01/010130071831.htm
NIH/National Institute On Aging. "Drug Decreases Blood Vessel Stiffness In Older Primates." ScienceDaily. www.sciencedaily.com/releases/2001/01/010130071831.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Ebola Lockdown

Sierra Leone in Ebola Lockdown

Reuters - News Video Online (Mar. 27, 2015) Millions of people in Sierra Leone are urged to stay at home in a three-day lockdown to help end the country&apos;s Ebola outbreak. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins